Stress Reactivity in Insomnia

失眠的应激反应

• 批准号: 7591771
• 负责人: Philip Richard Gehrman
• 金额: $ 21.62万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591771
• 关键词: Address; Adult; Affect; Age; American; Basic Science; Beds; Birds; CRH gene; Chronic Insomnia; Collection; Data; Development; Electroencephalography; Ethics; Etiology; Eye; Frequencies; Functional disorder; Future; Gender; Goals; Human; Hydrocortisone; Individual; Instruction; Laboratories; Lead; Link; Measures; Mediator of activation protein; Methods; Nature; Nervous System Physiology; Neurobiology; Outcome Measure; Patient Self-Report; Patients; Physiological; Play; Population; Positioning Attribute; Prevention; Primary Insomnia; Procedures; Process; Public Health; Relative (related person); Research; Research Personnel; Role; Saliva; Salivary; Sampling; Shock; Sleep; Sleep Disorders; Sleeplessness; Stress; Sympathetic Nervous System; System; Time; Wrist; Yohimbine; alpha-amylase; biological adaptation to stress; experience; falls; heart rate variability; improved; indexing; innovation; interest; neurobiological mechanism; novel; primary outcome; programs; psychological stressor; response; secondary outcome; sleep regulation; stressor

Insomnia is the most prevalent sleep disorder, affecting 6-10% of the U.S. population, and is associated with a number of daytime sequelae. However, little is known about the underlying neurobiological mechanisms that might lead to insomnia. There is preliminary evidence that the stress system may play a major role in the etiology of insomnia. The goal of the present study is to examine whether individuals with insomnia are more reactive to stress than healthy sleepers. We hypothesize that insomniacs will show heightened reactivity to the anticipation of a stressor. The proposed project will include 20 individuals with primary insomnia and 20 age- and gender-matched healthy sleeping controls. After collection of background measures and an adaptation night in the sleep laboratory, subjects will undergo a baseline and stress night. At 30 minutes before their habitual bedtime, upon awakening in the morning, and 30 minutes after waking up, subjects will provide a saliva sample and complete ratings of their current level of stress. On the adaptation and baseline nights no additional procedures will take place. On the stress night a mild electric shock will be administered to the subject after it is first demonstrated on the research personnel. They will then be told that they may receive up to 3 additional electric shocks during the night, although they will not actually receive any more shocks. The primary outcome measure is reactivity of sleep latency on the stress night compared to the baseline night. Secondary outcome measures are: subjective ratings of stress, salivary cortisol and alpha-amylase, sleep quantity and quality, high frequency EEG power, and heart rate variability. The results of this study will begin to determine whether the stress system plays a role in the neurobiology of insomnia. Increasing our understanding of the etiology of insomnia may improve prevention and treatment of the condition and reduce the large public health burden of insomnia.

失眠是最普遍的睡眠障碍，影响美国6-10%的人。 人群，并与一些日间后遗症。不过小 是已知的潜在的神经生物学机制，可能导致 失眠有初步证据表明，压力系统可能发挥主要作用， 失眠症的病因作用。本研究的目的是研究 失眠的人是否比健康的人更容易对压力做出反应 沉睡者我们假设失眠症患者会表现出更高的反应， 对压力源的预期。 拟议的项目将包括20名患有原发性失眠症的人， 20名年龄和性别匹配的健康睡眠对照组。采集后 背景测量和睡眠实验室中的适应性夜晚，受试者 将经历一个基准和压力之夜在他们习惯的30分钟前， 睡前，早上醒来时，醒来后30分钟， 受试者将提供唾液样本，并完成对他们目前的 应力在适应和基线夜晚， 地方在紧张的夜晚，将对患者进行轻度电击， 首先是在研究人员身上进行论证。于其后向业主悉数 被告知他们在夜间可能会受到多达3次的额外电击， 尽管它们实际上不会再受到任何冲击。主要结局 测量是压力之夜的睡眠潜伏期的反应性， 基线之夜次要结果测量是：压力的主观评级， 唾液皮质醇和α-淀粉酶，睡眠数量和质量，高频率 脑电图功率和心率变异性。这项研究的结果将开始，以确定是否应力系统 在失眠的神经生物学中起着重要作用。提高我们对 失眠的病因可能会改善预防和治疗的条件， 减轻失眠症给公众带来的巨大健康负担。