Catalytic applications of metal-organic frameworks

金属有机骨架的催化应用

• 批准号: EP/F007620/1
• 负责人: Andrew Burrows
• 金额: $ 16.24万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF007620%2F1
• 关键词: Catalytic; applications; metal; organic; frameworks

Catalysts increase the speed of reactions without themselves being changed. This research aims to develop a new series of solid catalysts that we intend to use to produce cyclic compounds using cycloaddition reactions. Our catalysts are metal-organic frameworks (abbreviated to MOFs) which are comprised of a grid-like assembly of metal atoms and organic linkers. MOFs are relatively new materials and use of them for catalysing reactions is very rare. They have, however, great promise as they contain pores in which the reactions occur, and the size and shapes of these pores can be controlled by altering the organic linkers thus altering the reaction conditions in the pores.Many natural and synthetic compounds are chiral, which means they can exist in left-handed and right-handed forms that are mirror images of each other. Chirality is important in the production of drugs as usually only one of the two possible left- or right-handed drug molecules is biologically active. We will investigate if by using chiral MOF catalysts we can produce reaction products that are themselves chiral i.e. only left or right-handed.To undertake these studies we intend to attack the problem from different points of view: 1) using synthetic chemistry to produce MOF catalysts in the laboratory and subsequently testing their viability for chiral cycloaddition reactions; 2) using computer simulations to predict how these catalysts could work at a molecular level; and 3) measuring the diffusion and adsorption properties of the catalysts to find out how the reagents move into the pores and how the molecules interact with the catalyst. By combining these three approaches we hope to produce more efficient catalysts that produce cycloaddition products in a pure state and as one chirality, either 'left' or 'right'.

催化剂在不改变自身的情况下提高反应速度。本研究旨在开发一系列新型的固体催化剂，用于环加成反应制备环状化合物。我们的催化剂是金属有机框架（缩写为MOFs），由金属原子和有机连接体的网格状组装体组成。MOFs是相对较新的材料，将其用于催化反应非常罕见。然而，它们有很大的希望，因为它们含有反应发生的孔，并且这些孔的大小和形状可以通过改变有机连接体从而改变孔中的反应条件来控制。许多天然和合成化合物是手性的，这意味着它们可以以彼此镜像的左手和右手形式存在。手性在药物生产中很重要，因为通常两种可能的左手或右手药物分子中只有一种具有生物活性。我们将研究通过使用手性MOF催化剂，我们是否可以产生本身是手性的反应产物，即只有左手或右手。为了进行这些研究，我们打算从不同的角度来解决这个问题：1）使用合成化学在实验室中制备MOF催化剂，随后测试它们用于手性环加成反应的可行性; 2）使用计算机模拟来预测这些催化剂如何在分子水平上工作;以及3）测量催化剂的扩散和吸附性质，以找出试剂如何移动到孔中以及分子如何与催化剂相互作用。通过结合这三种方法，我们希望产生更有效的催化剂，产生环加成产物在一个纯的状态和作为一个手性，无论是'左'或'右'。

项目成果

MOFs using calix[4]arene carboxylate linkers

使用杯[4]芳烃羧酸酯连接体的 MOF

• 发表时间: 2010
• 作者: Andrew D Burrows