Implications of in vivo muscle loading for hip fracture etiology

体内肌肉负荷对髋部骨折病因学的影响

基本信息

  • 批准号:
    7540156
  • 负责人:
  • 金额:
    $ 3.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-08-10 至 2011-08-09
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Project Summary: Muscles contribute directly to in vivo loading of the femur and normally protect the bone from exposure to damaging levels of shear and tensile stresses and strains. Age-related changes in the muscle loading experienced during daily activities could increase the rate of fatigue damage in the proximal femur, thus increasing the risk of hip fracture. The proposed research will investigate the effect of muscular loading on stresses and strains in the proximal femur during normal walking using a unique computational model. The first aim of this project is to investigate age-related changes in femoral stresses and strains due to muscular loading during gait. The second aim is to quantify the contributions of individual muscles to femoral stresses and strains during gait. This information will contribute to understanding of the causes of hip fractures, and in the long term could be used to improve diagnostic and preventive measures, decreasing the incidence of these debilitating injuries. A computational model will be developed to estimate the stresses and strains in the proximal femur during gait. This model will combine two computational techniques that are widely used in musculoskeletal biomechanics: static optimization and finite element modeling. Kinematics and ground reaction force data during gait will be recorded for 10 subjects ages 18-25 and 10 subjects ages 65-80. This data will be analyzed using inverse dynamics and static optimization to determine realistic values for the individual muscle forces acting on the femur throughout the gait cycle. Finite element models of the femur will be developed and, with the estimated muscle forces, used to predict the stresses and strains in the proximal femur during gait. The peak stresses/strains will be compared between age groups, and a sensitivity analysis performed to determine the importance of each muscle to the overall stress/strain state. Relevance: Hip fractures are one of the most serious healthcare problems facing older adults today due to high rates of post-fracture death and disability. This research will examine how age related changes in muscle loading during gait may contribute to the weakening and eventual fracture of the bone. Such information could lead to improved screening techniques and preventive measures to reduce the incidence of hip fractures.
描述(由申请人提供):项目总结:肌肉直接有助于股骨的体内负荷,通常保护骨免受剪切和拉伸应力和应变的破坏。日常活动中经历的肌肉负荷与年龄相关的变化可能会增加股骨近端的疲劳损伤率,从而增加髋部骨折的风险。拟议的研究将调查肌肉负荷对应力和应变的影响,在股骨近端正常行走使用一个独特的计算模型。本项目的第一个目的是研究步态过程中由于肌肉负荷引起的股骨应力和应变的年龄相关变化。第二个目的是量化的贡献,个别肌肉股骨应力和应变在步态。这些信息将有助于了解髋部骨折的原因,从长远来看,可用于改善诊断和预防措施,减少这些使人衰弱的损伤的发生率。将开发一个计算模型来估计步态期间股骨近端的应力和应变。该模型将联合收割机结合在肌肉骨骼生物力学中广泛使用的两种计算技术:静态优化和有限元建模。将记录10名年龄为18-25岁的受试者和10名年龄为65-80岁的受试者在步态期间的运动学和地面反作用力数据。将使用逆动力学和静态优化来分析这些数据,以确定在整个步态周期中作用在股骨上的个体肌肉力的实际值。将开发股骨的有限元模型,并使用估计的肌肉力量来预测步态期间股骨近端的应力和应变。将比较不同年龄组的峰值应力/应变,并进行敏感性分析,以确定每块肌肉对整体应力/应变状态的重要性。相关性:髋部骨折是当今老年人面临的最严重的医疗保健问题之一,因为骨折后死亡和残疾率很高。这项研究将探讨如何年龄相关的变化,在步态过程中肌肉负荷可能有助于削弱和最终骨折的骨头。这些信息可能会导致改善筛查技术和预防措施,以减少髋部骨折的发生率。

项目成果

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Dennis Anderson其他文献

Dennis Anderson的其他文献

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{{ truncateString('Dennis Anderson', 18)}}的其他基金

Age-related Changes in Thoracic Spine Biomechanics
胸椎生物力学与年龄相关的变化
  • 批准号:
    9144705
  • 财政年份:
    2015
  • 资助金额:
    $ 3.02万
  • 项目类别:
Age-related Changes in Thoracic Spine Biomechanics
胸椎生物力学与年龄相关的变化
  • 批准号:
    8712309
  • 财政年份:
    2013
  • 资助金额:
    $ 3.02万
  • 项目类别:
Age-related Changes in Thoracic Spine Biomechanics
胸椎生物力学与年龄相关的变化
  • 批准号:
    8580757
  • 财政年份:
    2013
  • 资助金额:
    $ 3.02万
  • 项目类别:
Implications of in vivo muscle loading for hip fracture etiology
体内肌肉负荷对髋部骨折病因学的影响
  • 批准号:
    7676740
  • 财政年份:
    2008
  • 资助金额:
    $ 3.02万
  • 项目类别:

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