Healthy Bodies, Healthy Hearts after Menopause

更年期后健康的身体、健康的心脏

• 批准号: 7488885
• 负责人: Margaret B Conroy
• 金额: $ 15.18万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7488885
• 关键词: Abdomen; Address; Adherence; Ancillary Study; Area; Arts; Behavior; Behavioral Medicine; Blood Vessels; Body Composition; Body Weight decreased; Cardiovascular Diseases; Cardiovascular system; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collection; Complex; Data; Development; Disease; Early Intervention; Effectiveness; Effectiveness of Interventions; Elderly; Electronic Health Record; Employee Strikes; Epidemiology; Exercise Physiology; Future; Genetic; Goals; Hand; Health; Health education; Heart; High Risk Woman; Incidence; Inflammation; Insulin Resistance; Intervention; Intervention Trial; Investigation; Link; Maintenance; Measurement; Measures; Mediating; Medicine; Menopause; Mentored Patient-Oriented Research Career Development Award; Methods; Modeling; Mollies; Morbidity - disease rate; Muscle; Numbers; Obesity; Outcome; Outcome Measure; Overweight; Participant; Pathway interactions; Patients; Physical Education; Physical activity; Physiological; Play; Population; Postmenopause; Prevention Research; Primary Health Care; Psychosocial Factor; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Research Methodology; Research Personnel; Risk; Risk Factors; Role; Support System; System; Testing; Time; Training; Translating; Translational Research; Translations; Universities; Weight; Woman; abdominal fat; abstracting; behavior change; cardiovascular disorder risk; career; cohort; experience; health care delivery; improved; innovation; lifestyle intervention; lipid metabolism; men; mortality; novel; novel strategies; nutrition; prevent; professor; programs; response; size; skills; therapy design; trend; young adult

DESCRIPTION (provided by applicant): Dr. Margaret (Molly) B. Conroy is an Assistant Professor of Medicine and Epidemiology at the University of Pittsburgh. She is applying for a Mentored Patient-Oriented Research Career Development Award (K23) in order to become an independent clinical investigator. Her proposal focuses on the relationships between physical activity, abdominal and muscular adiposity and cardiovascular disease (CVD) in women after menopause. Women are a high-risk population, as they are more likely to be physically inactive than men, a disparity that becomes more striking with advancing age. Following menopause, the incidence of CVD in women increases, while participation in regular physical activity declines. Further investigation is warranted of the pathways through which physical activity impacts CVD risk after menopause, particularly those incorporating body composition and potentially modifiable psychosocial factors. Dr. Conroy will examine these relationships and implement and evaluate a physical activity intervention in a clinical setting by pursuing three specific aims. Aim #1 will determine whether abdominal and muscular adiposity mediate the relationship between physical activity and subclinical cardiovascular disease risk in a cohort of postmenopausal women. Aim #2 will examine the relationships between changes in physical activity, abdominal and muscular adiposity and cardiovascular disease risk after an intensive lifestyle intervention. Aim #3 will involve a randomized, controlled physical activity intervention for early postmenopausal women that adapts clinical trial methods and translates them to the primary care patient population and practice setting. Aim #1 will be addressed by an ancillary study in the Women on the Move through Activity and Nutrition (WOMAN) cohort. Aim #2 will be addressed in the Slow Adverse Vascular Effects (SAVE) study. Aim #3 wiN be addressed by recruiting an intervention cohort from Dr. Conroy's primary care clinic. Experts in the fields of physical activity and CVD epidemiology, translational research, behavioral medicine and intervention design will supervise Dr. Conroy's career development. She will receive specific training in (1) collection, analysis and interpretation of state-of-the art outcome measures of obesity and subclinical cardiovascular disease; (2) theoretical background and hands-on skills necessary for planning and executing physical activity and lifestyle interventions; and (3) translational research, focused on strategies, collaborative models and technical support systems for implementing lifestyle interventions in clinical systems. A better understanding of the mechanisms linking physical activity, adiposity and CVD after menopause and innovative physical activity promotion strategies in this high-risk population are critical steps towards advancing cardiovascular health in women. (End of Abstract)

描述（由申请人提供）：Margaret (Molly) B. Conroy 博士是匹兹堡大学医学和流行病学助理教授。她正在申请指导患者导向的研究职业发展奖（K23），以便成为一名独立的临床研究者。她的提案重点关注绝经后女性的体力活动、腹部和肌肉肥胖与心血管疾病 (CVD) 之间的关系。女性是高危人群，因为她们比男性更有可能缺乏身体活动，随着年龄的增长，这种差异变得更加明显。绝经后，女性心血管疾病的发病率增加，而定期体育活动的参与度却下降。有必要进一步研究身体活动影响绝经后心血管疾病风险的途径，特别是那些结合身体成分和潜在可改变的心理社会因素的途径。康罗伊博士将检查这些关系，并通过追求三个具体目标在临床环境中实施和评估身体活动干预措施。目标#1将确定腹部和肌肉肥胖是否介导绝经后女性群体体力活动与亚临床心血管疾病风险之间的关系。目标#2 将研究强化生活方式干预后体力活动变化、腹部和肌肉肥胖与心血管疾病风险之间的关系。目标#3将涉及对绝经后早期女性进行随机、受控的体力活动干预，该干预将采用临床试验方法并将其转化为初级保健患者群体和实践环境。目标 #1 将通过“通过活动和营养进行活动的女性”(WOMAN) 队列中的一项辅助研究来解决。目标 #2 将在缓慢不良血管效应 (SAVE) 研究中得到解决。通过从 Conroy 医生的初级保健诊所招募干预队列可以实现目标#3。身体活动和心血管疾病流行病学、转化研究、行为医学和干预设计领域的专家将监督康罗伊博士的职业发展。她将接受以下方面的专门培训：(1) 收集、分析和解释肥胖和亚临床心血管疾病的最新结果指标； (2) 规划和执行身体活动和生活方式干预所需的理论背景和实践技能； (3) 转化研究，重点关注在临床系统中实施生活方式干预的策略、协作模型和技术支持系统。更好地了解绝经后体力活动、肥胖和心血管疾病之间的联系机制以及针对这一高危人群的创新体力活动促进策略是促进女性心血管健康的关键步骤。 （摘要完）