Sensory Processing in Subjects with Painful Bladder Syndrome

膀胱疼痛综合征患者的感觉处理

• 批准号: 7571247
• 负责人: TIMOTHY J NESS
• 金额: $ 22.06万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7571247
• 关键词: Affect; Anxiety; Basal Ganglia; Bladder; Blood flow; Cerebellum; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Comorbidity; Condition; Cutaneous; Data; Data Analyses; Depth; Diagnosis; Disease; Esthesia; Etiology; Evaluation; Exhibits; Female; Fibromyalgia; Figs - dietary; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Heating; Hypersensitivity; Ice; Image; Immersion Investigative Technique; Insula of Reil; Interstitial Cystitis; Interview; Invasive; Irritable Bowel Syndrome; Ischemia; Life; Measures; Medial; Mental Depression; Metabolic; Methods; Morbidity - disease rate; Muscle; National Institute of Diabetes and Digestive and Kidney Diseases; Neuraxis; Neurologic; Neuropsychological Tests; Numbers; Pain; Parietal; Patient Selection; Patients; Phenotype; Population; Process; Purpose; Questionnaires; Recruitment Activity; Reporting; Research Design; Research Personnel; Resistance; Sampling; Sampling Studies; Screening procedure; Sensory; Sensory Process; Site; Spin Labels; Staging; Standards of Weights and Measures; Stimulus; Stratification; Stress; Structure; Study Subject; Subgroup; Suggestion; Symptoms; Syndrome; Testing; Thalamic structure; Thinking; Time; TimeLine; Tissues; Upper Extremity; Visceral; Water; base; clinically relevant; cohort; experience; innovative technologies; interest; neurophysiology; neuropsychological; painful bladder syndrome; pressure; response; sex; urologic

Painful Bladder Syndrome (PBS) is a condition of bladder hypersensitivity that has proven resistant to diagnosis and treatment. PBS is symptom-based diagnoses similar to other disorders such as fibromyalgia (FM). Proposed etiologies for PBS are many, and include alterations in bladder component structure and function as well as changes in neurological structures related to the bladder. A single type of therapy is unlikely able to treat multiple pathophysiologies. The goal of this grant is to identify clinically relevant subgroups or separate phenotypes within the broader selection of patients that meet the criteria for PBS which would allow for a stratification of patients. In a limited sampling, quantitative sensory testing (QST) of PBS patients has found there to be a suggestion of two different phenotypes based on cutaneous sensory testing. Since one of the groups tests in a fashion that is similar to FM patients the following hypothesis is proposed; Patients with the diagnosis of painful bladder syndrome constitute two or more phenotypes that are distinguished by differential neurophysiological processing of sensory information. Further, these differing phenotypes can be predicted by the presence of absence of co-morbidity fibromyalgia. To test this hypothesis, neurophysiological processing will be assessed psychophysically using standard QST measure and neuropsychological questionnaires and neuroanatomically using an intracerebral bloodflow measure - Continuous Arterial Spin Label functional Magnetic Resonance Imaging (CASL-fMRI), an innovative technology.

膀胱疼痛综合征（PBS）是一种膀胱超敏反应的病症，已被证明对前列腺素具有耐药性。 诊断和治疗。PBS是一种基于糖尿病的诊断，类似于其他疾病，如纤维肌痛 （FM）.提出的PBS的病因有很多，包括膀胱组成结构的改变， 功能以及与膀胱相关的神经结构的变化。单一类型的治疗是 不太可能治疗多种病理生理学。该补助金的目标是确定临床相关的 符合PBS标准的更广泛患者选择中的亚组或单独表型 这将允许对患者进行分层。在有限的抽样中，定量感官测试（QST） PBS患者发现，基于皮肤感觉，存在两种不同表型的暗示。 试验.由于其中一组以类似于FM患者的方式进行测试，因此以下假设是 建议;诊断为膀胱疼痛综合征的患者构成两种或多种表型， 通过感觉信息的不同神经生理学处理来区分。此外，这些 不同的表型可以通过存在或不存在共病纤维肌痛来预测。为了验证这一 假设，神经生理学处理将使用标准QST测量进行精神病学评估 神经心理学问卷和神经解剖学使用脑内血流测量- 连续动脉自旋标记功能磁共振成像（CASL-fMRI），一种创新的 技术.