FOCUSED ULTRASOUND CORE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本提案的总体目标是利用二维超声相控阵列进行图像引导的热消融。二维相控阵提供了优于单聚焦换能器的几个优点。首先，在阵列中，焦点的位置由电子信号控制，因此不需要用机械定位装置物理地移动施加器来移动焦点位置。这种能力允许快速聚焦，从而可以跟踪移动目标。它还使超声处理系统的空间需求最小化，并允许快速移动焦点并同时产生多个焦点。其次，超声场的形状由驱动信号控制，从而允许从尖锐的细长焦点偏离。该特征使得可以扩大每次超声处理的凝固体积，并且优化每次处理的焦点形状，甚至在处理期间优化每次超声处理的焦点形状。最后，利用相控阵列施加器，可以使用波传播路径的成像信息来补偿由覆盖组织引起的超声波的失真。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of this proposal is to take an advantage of two dimensional ultrasound phased arrays for image guided thermal ablation. Two dimensional phased arrays offer several advantages over single focused transducers. First, in an array, the location of the focus is controlled by an electronic signal so it is not necessary to physically move the applicator with a mechanical positioning device to shift the focal location. This ability allows fast focusing, making it possible to track moving targets. It also minimizes the space requirements for the sonication system and allows one to rapidly move the focus and to generate multiple foci simultaneously. Second, the shape of the ultrasound field is controlled by the driving signals, thus allowing departure from a sharp, elongated focus. This feature makes it possible to enlarge the coagulated volume per sonication and to optimize the focal shape for each treatment and even for each sonication during a treatment. Finally, with a phased array applicator, distortions to the ultrasound wave induced by the overlying tissues can be compensated for using imaging information of the wave propagation path.