FOCUSED ULTRASOUND CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案的总体目标是利用二维超声相控阵进行图像引导的热消融。与单聚焦换能器相比，二维相控阵具有几个优点。首先，在阵列中，焦点的位置由电子信号控制，因此不需要用机械定位装置来物理地移动敷贴器来移动焦点位置。这一能力允许快速对焦，使跟踪移动目标成为可能。它还最大限度地减少了对声学系统的空间要求，并允许人们快速移动焦点并同时产生多个焦点。其次，超声场的形状由驱动信号控制，从而允许偏离尖锐、细长的焦点。这一特点使得有可能扩大每次超声治疗的凝固体积，并优化每次治疗的焦点形状，甚至在治疗期间的每一次超声波治疗。最后，使用相控阵施加器，可以利用波传播路径的成像信息来补偿由上覆组织引起的超声波失真。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of this proposal is to take an advantage of two dimensional ultrasound phased arrays for image guided thermal ablation. Two dimensional phased arrays offer several advantages over single focused transducers. First, in an array, the location of the focus is controlled by an electronic signal so it is not necessary to physically move the applicator with a mechanical positioning device to shift the focal location. This ability allows fast focusing, making it possible to track moving targets. It also minimizes the space requirements for the sonication system and allows one to rapidly move the focus and to generate multiple foci simultaneously. Second, the shape of the ultrasound field is controlled by the driving signals, thus allowing departure from a sharp, elongated focus. This feature makes it possible to enlarge the coagulated volume per sonication and to optimize the focal shape for each treatment and even for each sonication during a treatment. Finally, with a phased array applicator, distortions to the ultrasound wave induced by the overlying tissues can be compensated for using imaging information of the wave propagation path.