Transcostal High Intensity Focused Ultrasound for the Treatment of Cancer

经肋高强度聚焦超声治疗癌症

• 批准号: EP/F02617X/1
• 负责人: Constantin Coussios
• 金额: $ 75.17万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF02617X%2F1
• 关键词: Transcostal; Intensity; Focused; Ultrasound; Treatment

The efficacy of high intensity focused ultrasound (HIFU) for the non-invasive treatment of cancer has been clearly demonstrated for a range of different cancers including those of the liver, prostate and breast. As a non-invasive focal therapy, HIFU offers considerable advantages over other techniques such as chemotherapy and surgery, in terms of invasiveness and risk of harmful side-effects. Despite its advantages, however, there are a number of significant challenges currently hindering its widespread clinical application, specifically: the need to transmit energy through the rib cage and the associated risk of skin burns and damage to the rib surface, the effects of organ motion on treatment accuracy, a poor understanding of cavitation processes in vivo and, finally, the lack of effective techniques for real-time image guidance and treatment monitoring. The overall objective of the research programme described in this document is to develop practical solutions for these issues. Successful completion of this proposal will result in a prototype clinical device for the safe and effective HIFU treatment of tumours of the liver, kidney and pancreas that has undergone preclinical testing and conforms to the necessary safety standards for patient use.

高强度聚焦超声（HIFU）在非侵入性治疗癌症方面的疗效已被清楚地证明适用于一系列不同的癌症，包括肝癌、前列腺癌和乳腺癌。作为一种非侵入性局灶治疗，HIFU在侵入性和有害副作用风险方面比化疗和手术等其他技术具有相当大的优势。然而，尽管其具有优势，目前仍存在许多重大挑战阻碍其广泛的临床应用，特别是：需要通过胸腔传输能量以及相关的皮肤烧伤和肋骨表面损伤的风险，器官运动对治疗准确性的影响，对体内空化过程的了解不足，最后，缺乏有效的实时图像引导和治疗监测技术。本文件所述研究方案的总体目标是为这些问题制定切实可行的解决办法。该提案的成功完成将产生一种安全有效的HIFU治疗肝脏、肾脏和胰腺肿瘤的原型临床设备，该设备已经过临床前测试，符合患者使用的必要安全标准。

项目成果

Spatiotemporal quantification of therapeutically relevant cavitation for ablation and drug delivery by ultrasound

通过超声进行消融和药物输送的治疗相关空化的时空量化

• DOI: 10.1121/1.4708760
• 发表时间: 2012
• 期刊: The Journal of the Acoustical Society of America
• 作者: Coussios C

A Back-to-Base Experience of Human Normothermic Ex Situ Liver Perfusion: Does the Chill Kill?

• DOI: 10.1002/lt.25464
• 发表时间: 2019-06-01
• 期刊: LIVER TRANSPLANTATION
• 影响因子: 4.6
• 作者: Bral, Mariusz;Dajani, Khaled;Shapiro, A. M. James
• 通讯作者: Shapiro, A. M. James

The origins of nonlinear enhancement in ex vivo tissue during high intensity focused ultrasound ablation

高强度聚焦超声消融过程中离体组织非线性增强的起源

• DOI: 10.1121/1.4805957
• 发表时间: 2013
• 期刊: The Journal of the Acoustical Society of America
• 作者: Jackson E

Calibration of ultrasound backscatter temperature imaging for high-intensity focused ultrasound treatment planning.

用于高强度聚焦超声治疗计划的超声反向散射温度成像校准。

• DOI: 10.1016/j.ultrasmedbio.2013.04.001
• 发表时间: 2013
• 期刊: Ultrasound in medicine & biology
• 影响因子: 2.9
• 作者: Civale J

Shear-rate dependence of viscosity for improved modeling of cavitation dynamics in visco-elastic media.

粘度的剪切速率依赖性，用于改进粘弹性介质中空化动力学的建模。

• DOI: 10.1121/1.3508390
• 发表时间: 2010
• 期刊: The Journal of the Acoustical Society of America
• 作者: Labouret S