Copy of Development of methods for characterising and testing clinical High Intensity Focused Ultrasound (HIFU) systems

临床高强度聚焦超声 (HIFU) 系统表征和测试方法开发的副本

• 批准号: EP/F01564X/1
• 负责人: Constantin Coussios
• 金额: $ 15.04万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF01564X%2F1
• 关键词: Copy; Development; methods; characterising; testing

The clinical application of high intensity focused ultrasound (HIFU) to the treatment of soft tissue cancers of, for example, the liver, kidney and prostate, is a young and rapidly expanding field. To date more than 30,000 patients have been treated world wide. Successful treatment is achieved when the temperature of the tumour is raised to levels at which instantaneous cell death occurs. The focused beam ensures that only the tissue being targeted is heated, whilst surrounding tissue remains unharmed. Safe and effective use of HIFU requires that validated methods for measurement and testing of clinical devices should be made available as soon as possible. These issues have not been addressed to date in any systematic fashion. Clinical HIFU systems are currently assessed on an ad hoc basis by individual clinical departments and manufacturers, using methods, many of which are unpublished. There is, therefore, an urgent need to produce standard registration and testing equipment and methodology that allows users to characterize clinical HIFU systems for the purposes of checking safety and reproducibility of a machine's output, comparing different devices or commissioning new systems. The programme of work proposed is a mixture of adaptation and extension of existing and emerging techniques to meet the requirements of this new medical technology, and the development of novel methods specifically for this application.The overall aim of this project is to improve the efficacy, safety and range of applicability of clinical HIFU treatments by:A. providing validated methods for: * ultrasonic field characterisation using pressure field mapping and acoustic power measurement techniques; * HIFU system performance testing and quality assurance using novel thermal and cavitation mapping methods * patient exposure monitoring by means of electrical impedance measurements and real time acoustic power measurement;B. establishing a world leading HIFU characterisation facility at the Institute of Cancer Research (ICR);C. disseminating the successful methods, protocols and equipment to a wider user base through: * scientific publication; * contribution to written National and International Standards; * commercial exploitation.

高强度聚焦超声（HIFU）治疗软组织癌症（例如肝、肾和前列腺）的临床应用是一个年轻且迅速扩展的领域。迄今为止，全世界已有30 000多名患者接受了治疗。当肿瘤的温度升高到发生瞬时细胞死亡的水平时，就实现了成功的治疗。聚焦光束确保只有目标组织被加热，而周围组织保持不受伤害。安全有效地使用高强度聚焦超声要求尽快提供经确认的临床器械测量和测试方法。这些问题迄今尚未得到系统的解决。临床HIFU系统目前由各个临床部门和制造商使用方法进行临时评估，其中许多方法尚未发表。因此，迫切需要生产标准注册和测试设备和方法，其允许用户表征临床HIFU系统，以检查机器输出的安全性和再现性，比较不同的设备或调试新系统。本项目的总体目标是通过以下方式提高临床HIFU治疗的有效性、安全性和适用范围：A.对现有和新兴技术进行调整和扩展，以满足这一新医疗技术的要求;提供经验证的方法，用于：* 使用压力场映射和声功率测量技术的超声场表征; * 使用新的热和空化映射方法的HIFU系统性能测试和质量保证;* 通过电阻抗测量和真实的时间声功率测量的患者暴露监测;B.在癌症研究所（ICR）建立世界领先的HIFU表征设施;C.通过以下方式向更广泛的用户群传播成功的方法、规程和设备：* 科学出版物; * 为书面国家和国际标准提供资料; * 商业开发。

项目成果

Design and implementation of a cylindrical array for passive mapping of cavitation fields produced by clinical high intensity focused ultrasound transducers.

设计和实现用于临床高强度聚焦超声换能器产生的空化场无源测绘的圆柱形阵列。

• 作者: Stuart Faragher (Author)

Robust Capon beamforming for passive cavitation mapping during high-intensity focused ultrasound therapy.

用于高强度聚焦超声治疗期间被动空化映射的稳健 Capon 波束形成。

• DOI: 10.1121/1.3507982
• 发表时间: 2010
• 期刊: The Journal of the Acoustical Society of America
• 作者: Coviello C

evelopment of a tomographic cavitation sensor for quality assessment of clinical high intensity focused ultrasound systems.

开发用于临床高强度聚焦超声系统质量评估的断层扫描空化传感器。

• 作者: Constantin Coussios (Author)

Three-dimensional passive localization of cavitation activity for quality assessment of clinical high-intensity focused ultrasound devices.

空化活动的三维被动定位，用于临床高强度聚焦超声设备的质量评估。

• DOI: 10.1121/1.3507985
• 发表时间: 2010
• 期刊: The Journal of the Acoustical Society of America
• 作者: Faragher S

In vitro validation of three-dimensional cavitation-based pressure mapping for quality assessment of clinical high intensity focused ultrasound devices.

基于三维空化的压力映射的体外验证，用于临床高强度聚焦超声设备的质量评估。

• DOI: 10.1121/1.3587833
• 发表时间: 2011
• 期刊: The Journal of the Acoustical Society of America
• 作者: Faragher S