CORE

目前药物滥用研究翻译中心(CDART)的续签申请包括一份 核心和四个围绕个性差异这一中心主题联系在一起的项目 青春期和青春期药物滥用脆弱性的重要预测因素。以前的工作在 我们中心和其他实验室已经将感觉寻求确定为一种关键的人格结构 与毒品使用，特别是非法药物的使用密切相关。在目前的提案中，寻求轰动 将被分为两个独立的概念，即奖赏寻求和抑制，两者都被认为 与吸毒联系在一起。在项目1(Bardo，Pi)中，将使用实验室大鼠模型来确定 奖赏寻求和抑制的个体差异与兴奋剂自我给药有关 和中皮质边缘细胞突起。在项目2(Kelly，Pi)中，人类志愿者将被用来评估 个体在奖赏寻求和抑制上的差异与药物自我的差异有关 用功能磁共振成像和脑电地形图测量给药和神经功能。在项目3(Lynam，Pi)中， 从高中过渡到大学的学生将被用来确定个体在奖励上的差异 寻求和抑制与药物使用的开始、升级和/或停止有关 纵向设计。在项目4(齐默尔曼，PI)中，学生将被用于旨在 评估在寻求奖赏和抑制方面不同的个体对电视转播的反应是否不同 禁毒公益公告。 核心有三个具体目标：一个是科学的，一个是组织的，还有一个涉及 继续和扩大在翻译预防科学和药物滥用研究方面的领导作用 社区。关于这四个项目，核心的一些主要职能是：(1)提供专题 围绕奖赏寻求和抑制结构的不同项目的科学整合；(2) 在四个拟议项目和校园内其他正在进行的项目之间创造协同效应；(3)促进 基础科学和预防科学之间的跨学科协作使用神经行为和 心理社会层面的分析；以及(4)监督将我们的基础研究转化为 通过设计针对高危年轻人的更有效的禁毒公共服务公告来进行实践。

The current renewal application for the Center for Drug Abuse Research Translation (CDART) consists of a core and four projects that are linked around the central theme that individual differences in personality are important predictors of drug abuse vulnerability during adolescence and young adulthood. Previous work in our center and other laboratories has identified sensation seeking as a critical personality construct associated strongly with drug use, especially use of illicit drugs. In the current proposal, sensationseeking will be divided into two separate constructs, namely, reward seeking and inhibition, both of which are thought to be associatedwith drug use. In Project 1 (Bardo, PI), a laboratory rat model will be used to determine if individual differences in reward seeking and inhibition are associated with stimulant drug self-administration and mesocorticolimbic cellular processes. In Project 2 (Kelly, PI), human volunteers will be used to assess if individual differences in reward seeking and inhibition are associated with differences in drug self- administration and neural function as measured by fMRI and EEC. In Project 3 (Lynam, PI), a cohort of students transitioning from high school to college will be used to determine if individual differences in reward seeking and inhibition are associated with the initiation, escalation and/or cessation of drug use in a longitudinal design. In Project 4 (Zimmerman, PI), students will be used in experimental reserch designed to evaluate if individuals who vary in reward seeking and inhibition show a differential response to televised anti-drug public service announcements. There are three specific aims in the Core: one scientific, one organizational, and one that involves continuing and expanding leadership in translating the prevention science and drug abuse research communities. In relation to the four projects, some key functions of the Core are to: (1) provide thematic scientific integration of the different projects around the constructs of reward seeking and inhibition; (2) create synergy across the four proposed projects and other ongoing projects on campus; (3) facilitate interdisciplinary collaboration among basic and prevention sciences using both neurobehavioral and psychosocial levels of analysis; and (4) oversee the long-range goal of translating our basic research into practice by designing more effective anti-drug public service announements that target at-risk young adults.