CORE

药物滥用研究翻译中心（CDART）目前的续期申请包括 核心和四个项目，围绕中心主题，即个性的个体差异是 在青春期和青年期药物滥用脆弱性的重要预测因素。以前的工作 我们的研究中心和其他实验室已经将感觉寻求确定为一种批判性人格结构 与毒品使用，特别是非法药物的使用密切相关。在目前的提案中， 将分为两个独立的结构，即奖励寻求和抑制，两者都被认为是 to be associated关联with drug药物use.在项目1（Bardo，PI）中，将使用实验室大鼠模型确定是否 奖励寻求和抑制的个体差异与兴奋剂药物自我给药有关 和中皮质边缘细胞突起。在项目2（Kelly，PI）中，将使用人类志愿者来评估 奖赏寻求和抑制的个体差异与药物自我调节的差异有关。 通过fMRI和EEC测量给药和神经功能。在项目3（Lynam，PI）中， 从高中过渡到大学的学生将被用来确定奖励的个体差异 寻求和抑制与药物使用的开始、升级和/或停止有关， 纵向设计在项目4（齐默尔曼，PI）中，学生将被用于实验研究， 评估在奖励寻求和抑制方面不同的个体是否对电视节目表现出不同的反应。 禁毒公益广告。 核心有三个具体目标：一个是科学的，一个是组织的，一个是涉及 继续并扩大在转化预防科学和药物滥用研究方面的领导作用 社区.关于这四个项目，核心小组的一些主要职能是： 围绕奖赏寻求和抑制结构的不同项目的科学整合;（2） 在四个拟议项目和校园内其他正在进行的项目之间建立协同效应;（3）促进 基础科学和预防科学之间的跨学科合作， 社会心理层面的分析;（4）监督将我们的基础研究转化为 （c）通过设计针对高危青少年的更有效的禁毒公共服务公告，加强禁毒工作的实践。

The current renewal application for the Center for Drug Abuse Research Translation (CDART) consists of a core and four projects that are linked around the central theme that individual differences in personality are important predictors of drug abuse vulnerability during adolescence and young adulthood. Previous work in our center and other laboratories has identified sensation seeking as a critical personality construct associated strongly with drug use, especially use of illicit drugs. In the current proposal, sensationseeking will be divided into two separate constructs, namely, reward seeking and inhibition, both of which are thought to be associatedwith drug use. In Project 1 (Bardo, PI), a laboratory rat model will be used to determine if individual differences in reward seeking and inhibition are associated with stimulant drug self-administration and mesocorticolimbic cellular processes. In Project 2 (Kelly, PI), human volunteers will be used to assess if individual differences in reward seeking and inhibition are associated with differences in drug self- administration and neural function as measured by fMRI and EEC. In Project 3 (Lynam, PI), a cohort of students transitioning from high school to college will be used to determine if individual differences in reward seeking and inhibition are associated with the initiation, escalation and/or cessation of drug use in a longitudinal design. In Project 4 (Zimmerman, PI), students will be used in experimental reserch designed to evaluate if individuals who vary in reward seeking and inhibition show a differential response to televised anti-drug public service announcements. There are three specific aims in the Core: one scientific, one organizational, and one that involves continuing and expanding leadership in translating the prevention science and drug abuse research communities. In relation to the four projects, some key functions of the Core are to: (1) provide thematic scientific integration of the different projects around the constructs of reward seeking and inhibition; (2) create synergy across the four proposed projects and other ongoing projects on campus; (3) facilitate interdisciplinary collaboration among basic and prevention sciences using both neurobehavioral and psychosocial levels of analysis; and (4) oversee the long-range goal of translating our basic research into practice by designing more effective anti-drug public service announements that target at-risk young adults.