Social Cues and Drug Relapse

项目总结 药物滥用从业者面临的最大难题之一是持续的高复发率。 在治疗之后。虽然有多个内部状态和外部线索可能会引发复发，但有一个 共同的因素是与吸毒的社会同龄人重新建立联系。尽管最近的一些临床前工作已经 考察了社会影响对药物获得和维持自我管理的作用，有 基本上没有关于社交线索在恢复毒品寻觅中的作用的信息。总体假设 这个项目的特点是，自我管理的社会同龄人将作为一种线索，在受控的 临床前实验室设置。与离散提示(灯光、色调)和上下文提示(触觉和视觉)分开 线索，一天中的时间)，这些研究将确定社会同龄人是否也能够恢复灭绝 对毒品有反应。此外，这些研究将提供有关潜在互动的明确信息 社会和背景线索对复职的影响。提出了两个具体目标。首先，我们将 确定社会提示诱导复职是否存在性别差异，以及社会提示是否存在性别差异 增强上下文线索恢复毒品寻找的能力。第二，在这些行为实验中， C-Fos蛋白免疫反应细胞将在不同的脑区进行定量，以确定神经激活 遵循社交线索的男性和女性不同，或者社交线索的激活不同于上下文 暗示。如果社交线索被证明是毒品寻觅的导火索，这将提供证据，告知 强调技能培养以避免同伴越轨的心理社会治疗。

PROJECT SUMMARY One of the most difficult problems facing drug abuse practitioners is the continuing high rate of relapse following treatment. While there are multiple internal states and external cues that may trigger relapse, one common factor is to re-associate with drug-using social peers. Although some recent preclinical work has examined the role of social influence on acquisition and maintenance of drug self-administration, there is essentially no information about the role of social cues in reinstatement of drug seeking. The overall hypothesis of this project is that self-administering social peers will serve as a cue to induce drug seeking in a controlled preclinical laboratory setting. Separate from discrete cues (light, tone) and contextual cues (tactile and visual cues, time of day), these studies will determine if social peers also are able to reinstate extinguished responding for drug. In addition, these studies will provide definitive information about the potential interactive effects of social and contextual cues in reinstatement. Two specific aims are proposed. First, we will determine if there are sex differences in discriminative social cue-induced reinstatement and if social cues potentiate the ability of contextual cues to reinstate drug seeking. Second, in these of behavioral experiments, c-Fos protein immunoreactive cells will be quantitated in various brain regions to determine if neural activation following social cues differs between males and females or if activation by social cues differs from contextual cues. If social cues prove to be a trigger for drug seeking, this would provide evidence that informs psychosocial treatments which emphasize skill-building to avoid deviant peers.