SCOR

科学与行政核心A 科学和行政核心将是本次研究SCOR的核心组织力量。会的 提供科学和行政支持，进行翻译和跨学科研究，以解决 以下三个科学目标：(1)检查神经和心理生物效应中的性别差异 产前可卡因暴露(PCE)对增加药物滥用风险的压力相关因素的影响； 评估特定性别因素在压力、寻求毒品和易感性之间的关系中的作用 (3)通过咨询和研究支持建立科学合作关系，以 在地方和地区的调查人员中增加对特定性别对压力和药物滥用影响的研究 以及全国范围内。它将为在以下方面进行的基础科学和临床研究提供核心资源和支持 动物和人类的寿命。该核心的目标如下：(1)提供 中心目标的科学规划、整合、综合和监督，由首席调查员、 主任和执行委员会，并与科学咨询委员会协商；(2)提供 对SCOR、其组成部分和附属项目进行财政和行政监督；(3)提供 科学咨询和支持SCOR与初级和高级调查人员的研究合作 耶鲁大学和其他研究机构检查与压力和肥皂水有关的性别特定假说 各自研究的拟议具体目标；(4)协调人类受试者招募工作 SCOR项目，通过促进招募受试者，特别是妇女和少数群体来实现这些目标 中心及其组成部分和附属项目；(5)协助组成部分和附属项目 通过协调一致的数据收集、数据管理和统计分析方法 处理性激素和应激激素的实验室资源；(6)最大化个体产量 利用一组核心方法和评估进行研究，并协调培训评估 和方法；以及(7)促进SCOR之间在以下共同应激机制上的协作 为了研究影响应激相关障碍的生物和社会因素的异同 妇女健康。

Scientific and Administrative Core A The Scientific and Administrative Core will be the central organizing force for this research SCOR. It will provide scientific and administrative support to conduct translational and interdisciplinary studies to address the following three scientific goals: (1) to examine sex differences in the neural and psychobiological effects of prenatal cocaine exposure (PCE) on stress-related factors increasing risk of developing drug abuse; (2) to evaluate the effects of sex-specific factors in the association between stress, drug seeking and vulnerability to cocaine relapse; and (3) to build scientific collaborations through consultation and research support so as to increase the study of sex-specific effects on stress and drug abuse among investigators locally, regionally and nationally. It will provide Core resources and support to basic science and clinical studies conducted in animals and in humans across the lifespan. The aims of this Core will be the following: (1) To provide scientific planning, integration, synthesis and oversight of Center goals by the Principal Investigator, Co- Director and the Executive Committee, with consultation from the Scientific Advisory Board; (2) To provide fiscal and administrative oversight to the SCOR, its component and affiliated projects; (3) To provide scientific consultation and support to SCOR research collaborations with junior and senior investigators at Yale and at other research institutions to examine sex-specific hypotheses pertaining to stress and SUDs in the proposed specific aims of their respective research; (4) To coordinate human subject recruitment across SCOR projects by facilitating recruitment of subjects, especially women and minorities, to achieve the goals of the Center and its component and affiliated projects; (5) To assist component and affiliated projects through coordinated data collection, data management and statistical analysis approaches and in core laboratory resources for processing sex and stress hormones; (6) To maximize the yield across individual studies by utilizing a core battery of methods and assessments and coordinating the training of assessments and methods centrally; and (7) To facilitate inter-SCOR collaborations on common stress mechanisms in order to study similarities and differences in biological and social factors affecting stress-related disorders in women's health.