Center for Interdisciplinary Health Disparities Research

跨学科健康差异研究中心

• 批准号: 7286642
• 负责人: JOHN M HANSEN
• 金额: $ 125.2万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-18 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7286642
• 关键词: Center; Interdisciplinary; Health; Disparities; Research

The specific aims of the Center for Interdisciplinary Health Disparities Research are to: Aim #1: bring together scientists from inside and outside the University and members of the community who are especially vulnerable to adverse health conditions to inform the Center's scientific agenda; Aim #2: foster investigations that consider health disparities from multiple levels of analysis via shared conceptual frameworks that integrate discipline-specific theories and methods; Aim #3: increase interest in health disparities among scientist and students from various disciplines and from community members; Aim #4: develop measures and methods that are appropriate for use with vulnerable populations and that allow factors at various levels (social/environmental, behavioral/psychological, and biological/genetic) to be analyzed together; Aim #5: increase existing knowledge on the social, behavioral, and biological factors that influence health disparities and the nature of their interactions; and, Aim #6: disseminate findings through channels established through the Center to as wide an audience as possible, including members of vulnerable populations, community-based organizations and agencies, and scientific investigators inside and outside the University. In its first five years, the Center will focus on group differences in breast cancer, notably why Black women in the US and West Africa experience breast cancers that occur at a younger age and are more aggressive and lethal than those of White women. McClintock (R01 # 1), based on an animal model of social regulation of mammary tumor biology developed in her laboratory, will compare the gene regulation in mammary tumors and the ovarian function of socially isolated and group-living rats. OIopade (R01# 2) will (a) look at the molecular characterization of primary patient samples in Nigeria and Chicago's South Side to see if alterations in BRCA1 contribute to breast cancer in younger Black women and (b) explore the McClintock model in primary patient samples. Gehlert and Masi (R01# 3; CBPR) will explore emic views of breast cancer and its treatment and test the McClintock model with community volunteers. In the lalffer, they will examine neighborhood and community factors (such as collective efficacy and crime), living situations and social connectedness, behavioral responses (such as vigilance and perceived stress), and biological (e.g., cortisol levels) and health outcomes (most notably breast cancer). Conzen (R01# 4) will study rate of mammary tumor growth, response to chemotherapy, and chemoprevention in two animal models. The Tissue Core will provide analysis of mammary tissue. Coordination and dissemination will occur through the Administrative Core, by means of Faculty Colloquium and Monthly Speaker Series, In-Service and Summer Apprenticeship programs, a Center Web site and Web page for communication with other CPHHDs, etc.

跨学科健康差异研究中心的具体目标是：目标1：将大学内外的科学家和特别容易受到不利健康状况影响的社区成员聚集在一起，为中心的科学议程提供信息；目标2：通过整合学科特定理论和方法的共享概念框架，促进从多个层面分析考虑健康差异的调查；目标3：增加来自不同学科的科学家和学生以及社区成员对健康差异的兴趣；目标#4：制定适合于弱势群体的措施和方法，并允许各个层面的因素（社会/环境、行为/心理和生物/遗传）发挥作用