Center on Molecular and Cell Biology of Drug Abuse

描述(由申请人提供)： 药物滥用分子和细胞生物学基础研究中心(BRCMCDA)成立于1998年，目的是(1)促进药物成瘾研究的跨学科方法；(2)作为一个活动中心，协调和促进明尼苏达大学药物成瘾研究的所有学术和学术活动；(3)作为全国药物成瘾研究的分子和细胞生物学资源；(4)作为明尼苏达大学年轻科学家的培训中心。该中心的目标是促进药物成瘾研究的分子和细胞生物学方法，因此在8个科学部分中缺乏主题方案。相反，这些项目中的多学科方法为科学家之间的培训和互动提供了肥沃的土壤。该中心的活动包括主办研讨会和一年两次的研讨会，重点关注药物成瘾研究领域的最新技术和突破。该中心继续提高明尼苏达大学药物成瘾研究的知名度，并作为国家资源，为国内和国际研究人员的研究项目提供试剂和转基因小鼠。我们希望在过去成功的基础上，继续推动明尼苏达大学的药物成瘾研究和培训。因此，BRCMCBDA的拟议结构仍由8个科学部分组成，并由一个行政核心提供支助。参与这些构成部分的主要调查人员证明了过去的合作记录，并致力于中心的使命。然而，为了建立正式的招募机制，将实施“种子赠款”计划，为与该中心无关的调查人员创造机会，以检验他们在药物成瘾研究中的假设或新技术。这样的计划不仅将加强该中心内现有的研究计划，还将为该中心未来的组成部分奠定基础，并批准在药物成瘾研究中的应用。因此，与该中心的其他项目一起，BRCMCBDA将继续成为了解药物成瘾分子机制的研究培训中心和国家资源。

DESCRIPTION (provided by applicant): Basic Research Center on Molecular and Cell Biology of Drug Abuse (BRCMCDA) was established in 1998 with the objectives to (1) to foster interdisciplinary approaches in drug addiction research; (2) to serve as an "activity" center to coordinate and to promote all academic and scholarly activities on drug addiction research at University of Minnesota; (3) to serve as a national resource for molecular and cell biology of drug addiction research: and (4) to serve as training center for young scientists here at University of Minnesota. The goal of the Center is to promote molecular and cell biology approaches for drug addiction research, hence a thematic program is absent in the 8 scientific components. Instead, multidisciplinary approaches in the programs present fertile ground for training and interaction among scientists. The Center's activities include sponsored seminars and biannual symposium focus on the state-of-the-art techniques and breakthroughs in the field of drug addiction research. The Center has continued to raise the visibility of drug addiction research at University of Minnesota and has served as national resources in supplying investigators nationally and internationally reagents and genetically altered mice for their research programs. We wish to build on the past success and continue the missions of BRCMCBDA in promoting drug addiction research and training at University of Minnesota. Thus the proposed structure of BRCMCBDA remains to consist of 8 scientific components supported by an administrative core. The principal investigators involved in these components have demonstrated records of past collaboration and are committed to the mission of the Center. However, in order to establish a formal recruiting mechanism, a "seed grants" program will be implemented to create an opportunity for investigators not associated with the Center to test their hypotheses or new techniques in drug addiction research. Such program not only will enhance the existing research programs within the Center, but also will establish the bases for future components of the Center and grants application in drug addiction research. Hence, together with the other programs of the Center, BRCMCBDA will continue to be a research training center and national resource on the understanding of the molecular mechanism of drug addiction.