Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
基本信息
- 批准号:10089684
- 负责人:
- 金额:$ 5.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-05 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:3-Dimensional3D PrintAddressAngiogenic FactorAnimal ModelAnimalsAnteriorApplications GrantsArthrodesisAutologous TransplantationBiocompatible MaterialsBone GrowthBone RegenerationBone TransplantationCaringChemistryClinicalCoupledDefectDentalDental ModelsDevelopmentDevicesDorsalEncapsulatedEstersExhibitsFormulationFumaratesFundingGenerationsGoalsGoldGrowth FactorHumanHydrogelsHydroxyapatitesImplantIn SituInjectableInjectionsInstitutional Review BoardsInvestigationLaboratoriesLigamentsMandibleMechanicsMedialMinimally Invasive Surgical ProceduresModalityModelingMoldsMorbidity - disease rateMotionMusculoskeletalNatural regenerationNerveOperative Surgical ProceduresOralOrthopedicsOryctolagus cuniculusOsteogenesisOtolaryngologyPatientsPerformancePlant RootsPolymersPorosityProceduresProcessPropertyPsoas MusclesResearchSavingsShapesSheepSiteSolidSpecific qualifier valueSpinalSpinal FusionStructureSystemTechniquesTestingTimeTranslatingTranslationsTransplantationUnited States National Institutes of HealthVascular Endothelial Growth FactorsVertebral columnViscosityWorkallogenic bone transplantationbasebiodegradable polymerbiomaterial compatibilitybonebone morphogenetic protein 2caprolactonecatalystclinically relevantcontrolled releasecraniofacialcrosslinkdesignfirst-in-humanhealingin vivoinstrumentmaxillofacialmechanical propertiesmembermigrationminimally invasivenanonovelosteoinductive factorpoly(propylene fumarate)pre-clinicalprogramsreconstructionregenerativerelease factorrepairedscaffoldskeletalspine bone structuresuccessthree dimensional structure
项目摘要
Project Summary/Abstract
Many clinical situations in musculoskeletal care, including spinal arthrodesis procedures, require a bone
reconstruction strategy to treat contained defects (a hole in a bone), non-contained defects (a missing segment
of bone), or fusion across bone generation spaces (where bone would not normally grow). Novel orthopaedic
biomaterials that effect guided bone growth into biodegradable polymeric composite scaffolds are candidates
to address such requirements, and the goal that has motivated the development of these materials is the
augmentation and eventual elimination of current autograft and allograft bone strategies for transplantation into
skeletal sites. For the past decade, our laboratory has done extensive work on three-dimensional (3-D)
preformed bone scaffolds and transitioned them to clinically relevant large animal models for segmental bone
defect repair. The current proposal focuses on the translation of our injectable and moldable bone scaffold
work toward initial human use in spinal fusion via three integrated aims. In Aim 1, we will further optimize
members of our suite of biocompatible, biodegradable, and self-crosslinkable fumarate ester polymeric
biomaterial networks by inter-crosslinking of poly(propylene fumarate) (PPF) and poly(caprolactone) (PCL) via
catalyst-free click chemistry (PPF/PCL). The network will incorporate osteoconductive nano-hydroxyapatite
(nano-HA) and degradable hydrogel porogens that encapsulate vascular endothelial growth factor (VEGF) and
bone morphogenetic protein-2 (BMP-2). The VEGF-containing hydrogel will degrade faster than the BMP-
containing hydrogel to achieve dual, sequential delivery of angiogenic and osteoinductive factors coupled with
two-stage porosity generation. The composite PPF/PCL formulations will be optimized separately for injectable
and moldable bone scaffolds based on success criteria in rheological and handling properties, mechanical
properties, porosity and interconnectivity, degradation rates, and growth factor release profiles. In Aim 2, we
will determine the in vivo effect of the injectable and moldable PPF/PCL scaffold formulations in rabbit
interbody and posterolateral spinal fusion models, respectively. Due to the fact that the gold standard, autograft
bone, may incur donor site morbidity and can have a suboptimal fusion rate in some situations, spinal fusion is
often considered one of the most challenging applications of bone graft substitutes, thus allowing us to critically
evaluate the optimized candidate scaffold implant formulations. In Aim 3, we will assess the bone regeneration
performance of PPF/PCL composite scaffolds in a large animal model of clinically relevant human surgical
procedures as a translational step toward initial human use. We have selected a sheep unilateral posterior
spine pedicle screw instrumented reconstruction model, consisting of either a posterior interbody fusion, a
posterolateral intertransverse process fusion, or a combination of both these fusion processes at the same
level, utilizing our injectable and moldable scaffold strategies to accomplish these goals.
项目总结/文摘
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('Lichun Lu', 18)}}的其他基金
Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
- 批准号:
9908051 - 财政年份:2019
- 资助金额:
$ 5.05万 - 项目类别:
Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
- 批准号:
10364656 - 财政年份:2019
- 资助金额:
$ 5.05万 - 项目类别:
Injectable and Moldable Composite Bone Scaffolds for Spinal Fusion
用于脊柱融合的可注射和可成型复合骨支架
- 批准号:
10444098 - 财政年份:2019
- 资助金额:
$ 5.05万 - 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
- 批准号:
7796565 - 财政年份:2008
- 资助金额:
$ 5.05万 - 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
- 批准号:
8088220 - 财政年份:2008
- 资助金额:
$ 5.05万 - 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment - Master
转移性脊柱肿瘤:微创骨折风险分析和治疗 - 硕士
- 批准号:
8963947 - 财政年份:2008
- 资助金额:
$ 5.05万 - 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
- 批准号:
7428992 - 财政年份:2008
- 资助金额:
$ 5.05万 - 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
- 批准号:
8244358 - 财政年份:2008
- 资助金额:
$ 5.05万 - 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment
转移性脊柱肿瘤:微创骨折风险分析和治疗
- 批准号:
7599113 - 财政年份:2008
- 资助金额:
$ 5.05万 - 项目类别:
Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment - Master
转移性脊柱肿瘤:微创骨折风险分析和治疗 - 硕士
- 批准号:
10585673 - 财政年份:2008
- 资助金额:
$ 5.05万 - 项目类别:
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