Z Joint Changes in Low Back Pain Following Adjusting

调整后腰痛的 Z 关节变化

• 批准号: 7536880
• 负责人: Gregory D Cramer
• 金额: $ 3.84万
• 依托单位: NATIONAL UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7536880
• 关键词: Acute; Address; Adhesions; Anatomy; Anterior; Appointment; Blinded; Clinical; Control Groups; Data Analyses; Dimensions; Grouping; Joints; Low Back Pain; Lumbar Regions; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Outcome; Pain; Patients; Perception; Positioning Attribute; Posture; Purpose; Questionnaires; Randomized; Randomized Controlled Trials; Recruitment Activity; Research Personnel; Scanning; Score; Side; Spinal; Structure; Thinking; Title; Visual Analogue Pain Scale; Week; chiropracty; disability; follow-up; functional disability; healthy volunteer; improved functioning

The purpose of this continuation project (NIH/NCCAM # RO1 AT00123) is to use MRI to evaluate gapping of the zygapophysial (Z) joints following side-posture positioning and side-posture spinal adjusting in subjects with acute low back pain (LBP). A fundamental hypothesis of one of the beneficial effects of chiropractic spinal adjusting is that adhesions, developing in the Zjoints following hypomobility of these structures, are thought to be alleviated by separation (gapping) of the Zjoints through spinal adjusting. In the previous study, side-posture adjusting was found to gap the Z joints in healthy subjects. The aim of this study is to determine if differences can be measured in the L4/L5 and L5/S1 Z joint spaces during side-posture positioning and after lumbar side-posture spinal adjusting of 112subjects with acute LBP, and to determine if the amount of gapping is related to pain relief and improved function. Following 2 weeks of treatment, the subjects will be temporarily randomized into one of 4 MRI groups: 1)neutral positioning, followed by side-posture positioning (most painful side up);2) neutral positioning, followed by side-posture adjusting (most painful side up),followed by neutral positioning; 3) neutral positioning, followed by side-posture adjusting (most painful side up) and remaining in side-posture; and 4) (pure control group) neutral positioning, followed by very brief side-posture positioning, followed by neutral positioning. MRI scans will be taken with the subjects in the original neutral position and in the final position. Both MRI scans will be conducted consecutively over approximately 30 minutes (12:19 minutes per scan). All spinal adjustmentsgiven during this appointment will be performed directly on the MRI gantry table after the first scan. A second MRI appointment will occur 2 weeks later after 2 weeks of treatment. At the second MRI appointment, subjects will be assigned to the MRI group opposite to the one to which they were randomized during the first MRI appointment. Three observers, blinded to each other and to subject grouping, will make anterior-to-posterior measurements (A-P gap) of the Z joints directly from the MRI scans. The gapping difference between the second and first scans of each MRI appointment will be analyzed to determine if differences exist between the 4 groups and if the amount of gapping is related to relief of pain (difference in Visual Analog Scale from initial exam to MRI appointment) and disability (difference in Bournemouth Questionnaire scores). The results of this study will be used to increase understanding of the mechanism of action of lumbar side posture adjusting and side-posture positioning in acute LBP patients.

本继续项目（NIH/NCCAM # RO1 AT00123）的目的是使用MRI来评估