Alcoholism and Violence Among Native American Tribes

描述（由申请人提供）：项目概述。修订后的K23申请将允许Nicole P. Yuan博士在研究美洲原住民和其他弱势群体的酗酒和暴力方面发展技能和专业知识，重点是公共卫生和基于社区的研究方法。袁博士的职业发展计划包括：1)完成公共卫生硕士学位的要求，主修流行病学；2)酒精、遗传和美洲原住民健康流行病学和研究方法方面的培训；3)参加专业会议；4)完成研究计划；5)撰写实证论文和报告；6)提交R01资助申请。她的导师包括博士。玛丽·p·科斯，大卫·戈德曼，肯尼斯·伦纳德，邦妮·杜兰，伊维特·鲁比多和玛丽·z·梅斯。袁博士的研究计划包括三个阶段：1)对十部落研究的数据进行二次分析；2)试点研究与部落；3)研究合作，在部落充分参与的情况下开展后续研究。十部落研究是niaaa资助的一项合同，旨在确定七个美洲土著部落中酗酒的患病率，并测量酗酒的遗传和环境脆弱性因素。初步分析显示，终生酒精障碍和身体和性受害的流行率很高，部落间差异很大。袁博士的项目将包括原始合同中没有提出的分析。她的研究计划的具体目的是：1)研究基因-环境相互作用在酒精依赖发展中的作用；2)确定基因-环境相互作用在创伤后应激发展中的作用；3)研究文化因素对酒精依赖和受害风险的影响；4)开展一项试点研究，审查导致酒精障碍和人际暴力的文化和社区因素；5)建立合作，对酒精使用与亲密伴侣暴力之间的关系进行后续研究。的相关性。拟议的研究计划的目的是通过减少与酗酒和暴力有关的结果的流行和严重程度，改善美洲原住民及其社区的公共卫生。其影响包括为保留地服务的保健和其他社区系统提供更好的知情实践和政策。

DESCRIPTION (provided by applicant): PROJECT SUMMARY. This revised K23 application will allow Nicole P. Yuan, Ph.D. to develop skills and expertise in the study of alcoholism and violence among Native Americans and other vulnerable populations with emphasis on public health and community-based research methodologies. Dr. Yuan's career development plan includes: 1) completion of the requirements for an M.P.H. degree with a concentration in epidemiology; 2) training in alcohol, genetic, and Native American health epidemiology and research methods; 3) attendance at professional meetings; 4) completion of the research plan; 5) production of empirical papers and presentations; and 6) submission of an R01 grant application. Her mentors include Drs. Mary P. Koss, David Goldman, Kenneth Leonard, Bonnie M. Duran, Yvette Roubideaux, and Mary Z. Mays. Dr. Yuan's research plan consists of three phases: 1) secondary analyses of data from the Ten Tribes Study; 2) pilot study with the tribes; and 3) research collaboration to develop a follow-up study with full participation from the tribes. The Ten Tribes Study, a NIAAA-funded contract, was designed to determine prevalence rates of alcoholism and measure genetic and environmental vulnerability factors of alcoholism among seven Native American tribes. Preliminary analyses revealed high prevalence rates of lifetime alcohol disorders and physical and sexual victimization with significant inter-tribal variability. Dr. Yuan's project will include analyses that were not proposed in the original contract. The specific aims of her research plan are to: 1) to investigate the role of gene-environment interactions in the development of alcohol dependence; 2) determine the role of gene-environment interactions in the development of posttraumatic stress; 3) examine the impact of cultural factors on risks of alcohol dependence and victimization; 4) conduct a pilot study to examine cultural and community factors that contribute to alcohol disorders and interpersonal violence; and 5) establish collaborations to conduct a follow-up study on the relationship between alcohol use and intimate partner violence. RELEVANCE. The aim of the proposed research program is to improve the public health of Native Americans and their communities by reducing the prevalence and severity of outcomes associated with alcoholism and violence. Implications include better informed practice and policy of healthcare and other community-based systems serving reservations.