Oxidative Stress, Aging and Alzheimer's Disease

这个以指导患者为导向的研究事业奖的总体目标是通过对阿尔茨海默病事件、认知和运动功能改变以及死亡风险的危险因素进行流行病学研究，为申请人发展提供必要的工具，使其成为衰老和阿尔茨海默病的独立研究者。先前的研究表明阿尔茨海默病和帕金森症状密切相关，这增加了共同发病的可能性。我们建议将氧化应激作为阿尔茨海默病发生、认知功能改变、帕金森症状进展和死亡风险的危险因素进行研究。拟议的研究将利用900名参加宗教秩序研究（一项正在进行的关于衰老和阿尔茨海默病的流行病学研究）的无痴呆患者的冷冻血清样本，以及来自年度结构化临床评估的纵向临床数据。已经有大约150例偶发疾病和200例死亡。除了这个专注的、结构化的、及时的研究项目之外，职业发展计划还包括在一个非常成功的、多学科的环境中进行结构化的指导，以及一个将导致临床研究理学硕士学位的正式课程项目。

The overall goal of this Mentored Patient-Oriented Research Career Award is to provide the applicant Development with the necessary tools to become an independent investigator in aging and Alzheimer's disease, through the conduct of an epidemiologic study of risk factors for incident Alzheimer's disease, change in cognitive and motor function, and risk of death. Prior work suggesting that Alzheimer's disease and parkinsonian signs are strongly related, raises the possibility of shared etiopathogenesis. We propose to examine oxidative stress as a risk factor for incident Alzheimer's disease, change in cognitive function and progression of parkinsonian signs, and risk of death. The proposed study will take advantage of frozen serum specimens from 900 persons without dementia participating in the Religious Orders Study, an ongoing epidemiologic study of aging and Alzheimer's disease, and longitudinal clinical data from annual structured clinical evaluations. There are already approximately 150 cases of incident disease and 200 deaths. In addition to this focused, structured, and timely research project, the career development plans include structured mentoring in a highly successful, multidisciplinary environment, and a program of formal course work that will lead to a Masters of Science in Clinical Research.