Oxidative Stress, Aging and Alzheimer's Disease

这一以患者为导向的研究职业指导奖的总体目标是通过对阿尔茨海默病事件的风险因素、认知和运动功能的变化以及死亡风险进行流行病学研究，为申请者发展提供必要的工具，使其成为老龄化和阿尔茨海默病的独立调查者。先前的工作表明阿尔茨海默病和帕金森症状密切相关，这增加了共同病因的可能性。我们建议研究氧化应激作为阿尔茨海默病发病、认知功能改变和帕金森症状进展以及死亡风险的风险因素。这项拟议的研究将利用参加宗教秩序研究的900名非痴呆症患者的冷冻血清样本，这是一项正在进行的关于衰老和阿尔茨海默病的流行病学研究，以及来自年度结构化临床评估的纵向临床数据。目前已有大约150例发病病例和200例死亡病例。除了这个有重点、有组织、及时的研究项目外，职业发展计划还包括在一个非常成功的多学科环境中进行结构化指导，以及一个将导致临床研究理学硕士学位的正规课程工作计划。

The overall goal of this Mentored Patient-Oriented Research Career Award is to provide the applicant Development with the necessary tools to become an independent investigator in aging and Alzheimer's disease, through the conduct of an epidemiologic study of risk factors for incident Alzheimer's disease, change in cognitive and motor function, and risk of death. Prior work suggesting that Alzheimer's disease and parkinsonian signs are strongly related, raises the possibility of shared etiopathogenesis. We propose to examine oxidative stress as a risk factor for incident Alzheimer's disease, change in cognitive function and progression of parkinsonian signs, and risk of death. The proposed study will take advantage of frozen serum specimens from 900 persons without dementia participating in the Religious Orders Study, an ongoing epidemiologic study of aging and Alzheimer's disease, and longitudinal clinical data from annual structured clinical evaluations. There are already approximately 150 cases of incident disease and 200 deaths. In addition to this focused, structured, and timely research project, the career development plans include structured mentoring in a highly successful, multidisciplinary environment, and a program of formal course work that will lead to a Masters of Science in Clinical Research.