Oxidative Stress, Aging and Alzheimer's Disease

氧化应激、衰老和阿尔茨海默病

• 批准号: 7367080
• 负责人: Zoe Arvanitakis
• 金额: $ 15.49万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7367080
• 关键词: Age; Aging; Alzheimer' s Disease; Antioxidants; Autopsy; Award; Bradykinesia; Cerebrospinal Fluid; Cessation of life; Clinical Data; Clinical Research; Cognitive; Condition; DNA; Dementia; Deoxyguanosine; Development; Development Plans; Disease; Elderly; Environment; Epidemiologic Studies; Epidemiology; Episodic memory; Freezing; Gait abnormality; Goals; Hydroxyl Radical; Individual; K-Series Research Career Programs; Lead; Longitudinal Studies; Master of Science; Measures; Mentors; Motor; Muscle Rigidity; Nerve Degeneration; Neurodegenerative Disorders; Numbers; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Peripheral; Persons; Play; Population; Reactive Oxygen Species; Religion and Spirituality; Research; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Semantic memory; Serum; Short-Term Memory; Specimen; Speed; Structure; Testing; Thinking; Tremor; Urine; Visuospatial; Work; absorption; career; cognitive function; indexing; multidisciplinary; patient oriented research; programs; research clinical testing; tool

The overall goal of this Mentored Patient-Oriented Research Career Award is to provide the applicant Development with the necessary tools to become an independent investigator in aging and Alzheimer's disease, through the conduct of an epidemiologic study of risk factors for incident Alzheimer's disease, change in cognitive and motor function, and risk of death. Prior work suggesting that Alzheimer's disease and parkinsonian signs are strongly related, raises the possibility of shared etiopathogenesis. We propose to examine oxidative stress as a risk factor for incident Alzheimer's disease, change in cognitive function and progression of parkinsonian signs, and risk of death. The proposed study will take advantage of frozen serum specimens from 900 persons without dementia participating in the Religious Orders Study, an ongoing epidemiologic study of aging and Alzheimer's disease, and longitudinal clinical data from annual structured clinical evaluations. There are already approximately 150 cases of incident disease and 200 deaths. In addition to this focused, structured, and timely research project, the career development plans include structured mentoring in a highly successful, multidisciplinary environment, and a program of formal course work that will lead to a Masters of Science in Clinical Research.

这项以患者为导向的研究职业奖的总体目标是通过对阿尔茨海默病的风险因素、认知和运动功能的变化以及死亡风险进行流行病学研究，为申请人提供必要的工具，使其成为衰老和阿尔茨海默病的独立研究者。先前的研究表明阿尔茨海默病和帕金森病症状密切相关，这提出了共同发病机制的可能性。我们建议将氧化应激作为阿尔茨海默病、认知功能变化和帕金森病症状进展以及死亡风险的危险因素进行研究。拟议的研究将利用参加宗教团体研究（一项正在进行的关于衰老和阿尔茨海默病的流行病学研究）的 900 名无痴呆症患者的冷冻血清样本，以及来自年度结构化临床评估的纵向临床数据。已经有大约 150 例病例和 200 人死亡。除了这个重点突出、结构化和及时的研究项目之外，职业发展计划还包括在非常成功的多学科环境中进行结构化指导，以及获得临床研究理学硕士学位的正式课程计划。