Training in Translational Develomental Neuroscience

描述（由申请人提供）：我们正在进入一个前所未有的时代，以了解和治疗发育中的神经系统疾病，这需要巨大的痛苦和成本。遗传学、分子和细胞生物学、系统和行为神经科学以及生物信息学的最新进展为我们提供了强大的新工具和概念，可用于发现儿童神经系统疾病的原因并创造有效的治疗方法。我们并不缺乏好的想法和工具，可以切实有效地为减轻儿童神经系统疾病的负担而努力。但成功的道路上仍有一些重要的障碍：神经科学研究界对发育中的神经系统疾病的重视程度较低；工业对发育障碍的重视程度较低；神经科学的发现和新疗法之间的脱节。要想成功地解决发育障碍问题，我们需要培养一批有才华的研究人员，他们的培训使他们能够在转化发育神经科学领域担任领导角色。我们提出了一个培训计划，将临床儿童神经学和基础或临床科学研究的卓越性与了解如何将新见解转化为护理进步所需的经验相结合。在斯坦福大学医学院的支持下，由专门的教师组织，并聘请了一群有才华的导师，该项目包括：1)临床儿童神经病学方面的卓越表现，2)发育神经科学方面的基础或临床研究指导，3)临床试验设计和实施方法方面的经验，4)转化研究方面的培训，5)接触用于定义和开发新疗法的概念和方法。“转化发育神经科学”项目将培养能够成功将发育神经科学的见解转化为新疗法的儿童神经学家和神经科学家。

DESCRIPTION (provided by applicant): We are entering an era of unprecedented opportunities for understanding and treating disorders of the developing nervous system, which exact immense suffering and cost. Recent advances in genetics, molecular and cellular biology, systems and behavioral neuroscience, and bioinformatics have provided us with powerful new tools and concepts that can be used to both discover the cause of childhood neurological disorders and to create effective therapies. There is no paucity of good ideas and tools with which to work tangibly and with success toward alleviating the burden of neurological disorders in children. But there are important roadblocks to success: the low priority given to disorders of the developing nervous system by the neuroscience research community; the low priority given to developmental disorders by industry; and the disconnection between neuroscience discovery and the delivery of new treatments. Moving forward an agenda that successfully addresses developmental disorders requires that we create a talented cadre of investigators whose training prepares them to take on leadership roles in translational developmental neuroscience. We propose a training program that combines excellence in clinical Child Neurology and in basic or clinical science research with the experience needed to understand how new insights are translated into advances in care. Organized by a dedicated faculty, supported by Stanford University School of Medicine, and engaging a talented group of mentors, the program incorporates: 1) excellence in clinical Child Neurology, 2) mentored basic or clinical research in developmental neuroscience, 3) experience in the methods of design and conduct of clinical trials, 4) training in translational research and 5) exposure to the concepts and methods used to define and develop new therapies. The program in "Translational Developmental Neuroscience" will produce child neurologist-neuroscientists that can successfully translate developmental neuroscience insights into new treatments.