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Training in Translational Develomental Neuroscience

转化发育神经科学培训

基本信息

批准号：
7487889
负责人：
Paul Graham Fisher
金额：
$ 47.55万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-08-15 至 2011-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): We are entering an era of unprecedented opportunities for understanding and treating disorders of the developing nervous system, which exact immense suffering and cost. Recent advances in genetics, molecular and cellular biology, systems and behavioral neuroscience, and bioinformatics have provided us with powerful new tools and concepts that can be used to both discover the cause of childhood neurological disorders and to create effective therapies. There is no paucity of good ideas and tools with which to work tangibly and with success toward alleviating the burden of neurological disorders in children. But there are important roadblocks to success: the low priority given to disorders of the developing nervous system by the neuroscience research community; the low priority given to developmental disorders by industry; and the disconnection between neuroscience discovery and the delivery of new treatments. Moving forward an agenda that successfully addresses developmental disorders requires that we create a talented cadre of investigators whose training prepares them to take on leadership roles in translational developmental neuroscience. We propose a training program that combines excellence in clinical Child Neurology and in basic or clinical science research with the experience needed to understand how new insights are translated into advances in care. Organized by a dedicated faculty, supported by Stanford University School of Medicine, and engaging a talented group of mentors, the program incorporates: 1) excellence in clinical Child Neurology, 2) mentored basic or clinical research in developmental neuroscience, 3) experience in the methods of design and conduct of clinical trials, 4) training in translational research and 5) exposure to the concepts and methods used to define and develop new therapies. The program in "Translational Developmental Neuroscience" will produce child neurologist-neuroscientists that can successfully translate developmental neuroscience insights into new treatments.

描述（由申请人提供）：我们正在进入一个前所未有的时代，了解和治疗发育中的神经系统疾病的机会，这确实是巨大的痛苦和成本。遗传学，分子和细胞生物学，系统和行为神经科学以及生物信息学的最新进展为我们提供了强大的新工具和概念，可用于发现儿童神经系统疾病的原因并创建有效的治疗方法。有很多好的想法和工具，可以切实有效地减轻儿童神经系统疾病的负担。但是，成功的道路上也有重要的障碍：神经科学研究界对发育中的神经系统疾病的重视程度较低;工业界对发育障碍的重视程度较低;神经科学发现与新疗法的提供之间存在脱节。推进一个成功解决发育障碍的议程，需要我们创建一个有才华的调查人员骨干，他们的培训使他们能够在转化发展神经科学中发挥领导作用。我们提出了一个培训计划，结合了卓越的临床儿童神经病学和基础或临床科学研究与所需的经验，以了解如何将新的见解转化为护理的进步。该计划由专门的教师组织，由斯坦福大学医学院支持，并聘请了一批才华横溢的导师，该计划包括：1）在临床儿童神经学方面的卓越表现，2）指导过发育神经科学的基础或临床研究，3）在临床试验的设计和实施方法方面的经验，4）转化研究的培训和5）接触用于定义和开发新疗法的概念和方法。在“转化发育神经科学”计划将产生儿童神经学家神经科学家，可以成功地将发展神经科学的见解转化为新的治疗方法。