Analytical Microscopy Core

分析显微镜核心

• 批准号: 7576881
• 负责人: STEPHEN Bruce DOTY
• 金额: $ 18.45万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7576881
• 关键词: Biomedical Research; Cells; Chemistry; Classification; Confocal Microscopy; Core Facility; Development; Electrons; Environment; Equipment; Goals; Histocytochemistry; Histology; Institution; Knowledge; Laboratories; Life; Light; Mechanics; Microscopic; Microscopy; Morphology; Musculoskeletal; Operative Surgical Procedures; Orthopedics; Quantitative Evaluations; Research; Research Personnel; Special Hospitals; Technical Expertise; Techniques; Tissues; Training; United States; Work; base; design; immunocytochemistry; interest; morphometry; programs; repaired

The major goal of the Analytical Microscopy Laboratory is to provide technical expertise in qualitative and quantitative analytical microscopy and to extend these capabilities to all relevant studies in orthopaedics and musculoskeletal research. The Analytical Microscopy Core has four major objectives: 1. To provide morphological techniques and analysis for the study of soft and hard tissues at the light and electron microscopic levels for research programs involving investigators within the biomedical research base at the Hospital for Special Surgery (HSS) and its affiliated institutions; 2. To provide information and training to all investigators regarding the use of techniques in histology, histochemistry, immunocytochemistry and morphometry; 3. To develop further our capacity for systematic and quantitative evaluation of fixed arid living cells analyzed by microscopic techniques (including confocal microscopy); and, 4. To develop new applications of microscopic techniques to fit the research programs of investigators within the Core Center's biomedical research base. This laboratory is unique because the techniques, technical support, and equipment is specifically designed to aid in the study of all musculoskeletal tissues, whether mineralized or not. In addition, the studies can be done at any level of interest from the gross to the subcellular, and because of the working relationships with the other cores, each study can be investigated for change in morphology, chemistry, and mechanics or architec-ture. This environment is very unique and probably does not exist anywhere else in the United States. Because of these strengths, the projects and studies being supported will add significantly to our knowledge of musculoskeletal tissue development and repair.

分析显微镜实验室的主要目标是提供定性和 定量分析显微镜，并将这些能力扩展到骨科和 肌肉骨骼研究。 分析显微镜核心有四个主要目标： 1。提供形态学技术和分析，以研究光和硬组织 研究计划的电子显微镜水平，涉及生物医学研究中的研究人员 基于特殊手术医院（HSS）及其附属机构； 2。为所有研究人员提供有关组织学中技术使用的信息和培训， 组织化学，免疫细胞化学和形态计量学； 3。进一步发展我们对固定干旱活细胞进行系统和定量评估的能力 通过微观技术（包括共聚焦显微镜）分析；和， 4。开发微观技术的新应用以适合研究人员的研究计划 在核心中心的生物医学研究基础内。 该实验室之所以独特，是因为技术，技术支持和设备是专门设计的 有助于研究所有肌肉骨骼组织，无论是否矿化。另外，研究可能是 从总体到亚细胞的任何兴趣级别完成，并且由于与 其他核心，每个研究都可以研究形态，化学和力学的变化或 建筑学。这个环境非常独特，可能不存在联合的其他任何地方 国家。由于这些优势，支持的项目和研究将大大增加我们的 了解肌肉骨骼组织的发育和修复。