Hypoxia-inducible factor-1 (HIF-1): Pharmacological and molecular insights into its role in brain protection

缺氧诱导因子 1 (HIF-1)：其脑保护作用的药理学和分子学见解

• 批准号: nhmrc : 568769
• 负责人: Dr Nicole Jones
• 金额: $ 19.55万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hypoxia-inducible-factor-brain-protection/98422
• 关键词: Hypoxia; inducible; factor; HIF; Pharmacological

At present, there are no effective therapies for reducing brain damage which can occur after acute brain insults including birth asphyxia. This project aims to study whether increasing a naturally occurring protective protein (HIF) in the brain can minimize brain damage in a model of perinatal brain injury. We plan to validate HIF as a novel therapeutic target for reduce brain injury and promote brain repair processes.

目前，还没有有效的治疗方法来减少急性脑损伤（包括出生窒息）后可能发生的脑损伤。本项目旨在研究在围产期脑损伤模型中，增加大脑中天然存在的保护蛋白（HIF）是否可以最大限度地减少脑损伤。我们计划验证HIF作为减少脑损伤和促进脑修复过程的新治疗靶点。