Application of a High Field and High Resolution MRI to Tribological Studies of Articular Cartilage

高场高分辨率 MRI 在关节软骨摩擦学研究中的应用

• 批准号: EP/F040792/1
• 负责人: Zhongmin Jin
• 金额: $ 72.33万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF040792%2F1
• 关键词: Application; Field; Resolution; MRI; Tribological

Understanding the lubrication mechanism in healthy synovial joints such as hips and knees is important for not only understanding how these natural bearings operate in the human body but also developing intervention therapies. The unique load bearing material of articular cartilage in synovial joints is porous and elastic filled with water. Under loading, the interstitial water flows and supports a large percentage of external loading. The aims of this proposal are to develop and apply an advanced high resolution MRI to the lubrication studies of articular cartilage. The main objectives include the development of the MRI imaging methodology and design and development of a small scale experimental lubrication rig to be used inside the MRI to measure deformation, friction and wear. Once these methodologies are developed, applications will be made on both normal and degenerated tissues. Understanding the fluid flow and lubricating capacity for healthy and degenerated cartilage specimens in a range of loading conditions is important as cartilage substitution interventions and tissue engineering therapies are being developed. The outcome from the proposed research will provide timely guidelines for pre-clinical evaluation of these treatment options, and provide knowledge for the regulatory and standards bodies. This will have tremendous economic benefits to the UK NHS as well as clinical benefits to patients.

了解健康滑膜关节（如髋关节和膝关节）的润滑机制不仅对了解这些自然轴承在人体中的运作方式很重要，而且对开发干预疗法也很重要。滑膜关节软骨的独特承重材料是多孔的，充满水的弹性。在荷载作用下，间隙水流动并支撑很大比例的外部荷载。本提案的目的是发展和应用先进的高分辨率MRI关节软骨的润滑研究。主要目标包括MRI成像方法的开发，以及小型实验润滑装置的设计和开发，该装置将用于MRI内部测量变形、摩擦和磨损。一旦这些方法被开发出来，将应用于正常组织和退化组织。随着软骨替代干预和组织工程疗法的发展，了解健康和退化软骨标本在各种加载条件下的流体流动和润滑能力是很重要的。拟议研究的结果将为这些治疗方案的临床前评估提供及时的指导，并为监管和标准机构提供知识。这将对英国国民医疗服务体系产生巨大的经济效益，对患者也有临床效益。

项目成果

Hip contact forces in asymptomatic total hip replacement patients differ from normal healthy individuals: Implications for preclinical testing

无症状全髋关节置换术患者的髋部接触力与正常健康个体不同：临床前测试的意义

• DOI: 10.1016/j.clinbiomech.2014.06.005
• 发表时间: 2014
• 期刊: Clinical Biomechanics
• 影响因子: 1.8
• 作者: Li J

The influence of kinematic conditions and design on the wear of patella-femoral replacements.

• DOI: 10.1177/0954411913518910
• 发表时间: 2014-02
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Maiti R;Fisher J;Rowley L;Jennings LM
• 通讯作者: Jennings LM

Biphasic investigation of contact mechanics in natural human hips during activities.

• DOI: 10.1177/0954411914537617
• 发表时间: 2014-06
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Li J;Hua X;Jin Z;Fisher J;Wilcox RK
• 通讯作者: Wilcox RK