Tribological Modelling of Biphasic Articular Cartilage and Cartilage Replacement Systems in Anatomical and Physiological Models

解剖学和生理学模型中双相关节软骨和软骨替代系统的摩擦学建模

• 批准号: EP/D036593/1
• 负责人: Zhongmin Jin
• 金额: $ 22.98万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD036593%2F1
• 关键词: Tribological; Modelling; Biphasic; Articular; Cartilage

Treatment of end stage arthritis currently involves major surgical intervention in the form of total joint replacement. However, due to the clinical limitation of these devices (generally less than 15 years), there are concerns about their use in increasing numbers of younger patients with arthritis of the major load bearing joints without a secondary operation. Consequently, there are emerging interests in earlier intervention approaches such as partial surface replacement and cartilage substitution, which attempt to retain some or all of the functional bearing surface of articular cartilage. The increasingly rigorous ethical and regulatory environment is demanding more extensive pre-clinical studies, as part of the translation of any new technology to the patient. However, there are currently no pre-clinical functional simulation models that can be used to assess the potential long-term clinical performance of these devices which articulate against articular cartilage. The aims of this project are to develop novel computational models for investigating the tribology (friction, wear and lubrication) of articular cartilage in order to understand the normal function as well as to provide guidance for developing early intervention cartilage substitution solutions in the hip joint. The computational model will particularly focus on the biphasic (fluid and solid phases) loading carrying capacity of articular cartilage and integrate contact mechanics, friction, lubrication and wear using an anatomical and physiological joint model. Both cartilage against cartilage and cartilage against a biomaterial such as metal (hemi-arthroplasty) will be modelled. The computational model will be validated using a porcine hip joint model before use on the human hip joint. The outcome of the proposed research will provide guidance for developing novel tissue substitution solutions in the future.

终末期关节炎的治疗目前涉及全关节置换形式的大手术干预。然而，由于这些器械的临床局限性（通常小于15年），人们担心它们在越来越多的主要承重关节关节炎年轻患者中的使用无需二次手术。因此，在早期的干预方法，如部分表面置换和软骨替代，试图保留一些或所有的关节软骨功能的轴承表面出现的兴趣。日益严格的伦理和监管环境要求进行更广泛的临床前研究，作为将任何新技术转化为患者的一部分。然而，目前没有临床前功能模拟模型可用于评估这些与关节软骨接合的器械的潜在长期临床性能。该项目的目的是开发新的计算模型，用于研究关节软骨的摩擦学（摩擦，磨损和润滑），以了解正常功能，并为开发髋关节早期干预软骨替代解决方案提供指导。计算模型将特别关注关节软骨的双相（流体和固相）载荷承载能力，并使用解剖和生理关节模型整合接触力学、摩擦、润滑和磨损。将对软骨对软骨和软骨对生物材料（如金属（半关节成形术））进行建模。在用于人体髋关节之前，将使用猪髋关节模型对计算模型进行确认。拟议研究的结果将为未来开发新型组织替代解决方案提供指导。

项目成果

A steady-state elastohydrodynamic lubrication model aimed at natural hip joints with physiological loading and anatomical position

针对具有生理负荷和解剖位置的自然髋关节的稳态弹流动力润滑模型

• DOI: 10.1243/13506501jet332
• 发表时间: 2008
• 期刊: Journal of Engineering Tribology
• 作者: Quiñonez A

Modelling of fluid support inside articular cartilage during sliding

• DOI: 10.1243/13506501jet241
• 发表时间: 2007-05-01
• 期刊: PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
• 影响因子: 2
• 作者: Pawaskar, S. S.;Jin, Z. M.;Fisher, J.
• 通讯作者: Fisher, J.

An analytical solution for the radial and tangential displacements on a thin hemispherical layer of articular cartilage.

关节软骨薄半球层上的径向和切向位移的解析解。

• DOI: 10.1007/s10237-010-0234-6
• 发表时间: 2011
• 期刊: Biomechanics and modeling in mechanobiology
• 影响因子: 3.5
• 作者: Félix Quiñonez A

Effect of load variation on the friction properties of articular cartilage

• DOI: 10.1243/13506501jet240
• 发表时间: 2007-05-01
• 期刊: PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
• 影响因子: 2
• 作者: Katta, J.;Pawaskar, S. S.;Fisher, J.
• 通讯作者: Fisher, J.