Understanding the role of endogenous siRNAs in the maintenance of genomic defenses

了解内源 siRNA 在维持基因组防御中的作用

• 批准号: DP140103481
• 负责人: Dr Danny Rangasamy
• 金额: $ 4.1万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-04-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140103481
• 关键词: Understanding; role; endogenous; siRNAs; maintenance

The inappropriate expression of retrotransposons can cause increased genomic instability. The underlying molecular pathways that control retrotransposon expression are not known. This project proposes to investigate this question at a molecular level how naturally occurring small endogenous noncoding RNAs (endo-siRNAs) enforce the epigenetic silencing of retrotransposons and examine the likely impact of endo-siRNAs expression in the packaging and maintenance of retrotransposons. Understanding this fundamental question will advance the scientific knowledge of small RNA functions in our genomic defense systems.

反转录转座子的不适当表达可导致基因组不稳定性增加。控制反转录转座子表达的潜在分子途径尚不清楚。本项目拟在分子水平上研究天然存在的内源性小非编码RNA（endo-siRNAs）如何增强逆转录转座子的表观遗传沉默，并研究endo-siRNAs表达在逆转录转座子包装和维持中的可能影响。理解这个基本问题将推进我们基因组防御系统中小RNA功能的科学知识。