Understanding how opioids affect the experiential and neural signatures of feelings of social connection with close others

了解阿片类药物如何影响与亲密他人的社会联系感受的体验和神经特征

基本信息

批准号：
10612451
负责人：
Tristen K. Inagaki
金额：
$ 61.01万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612451
关键词：
Address Adult Affect Affective Animal Model Animals Back Behavior Biological Biological Factors Blinded Brain Brain region Brain scan Clinical Drug Prescriptions Effectiveness Family Feeling Female Friends Functional Imaging Future Health Human Insula of Reil Interdisciplinary Study Intervention Knowledge Laboratories Life Link Literature Maintenance Maintenance Therapy Measures Mediating Medical Methods Naltrexone Neurobiology Neurosecretory Systems Opiate Addiction Opioid Opioid Antagonist Opioid Receptor Outcome Pain management Participant Pathway interactions Patient Self-Report Personal Satisfaction Persons Pharmaceutical Preparations Pharmacology Placebos Prefrontal Cortex Prevention Process Prospective Studies Protocols documentation Public Health Randomized Randomized, Controlled Trials Recovery Reporting Research Research Personnel Role Sampling Social isolation Specific qualifier value Standardization Stimulus Testing Time Variant Ventral Striatum Woman Work addiction biological adaptation to stress biopsychosocial combat design endogenous opioids experience interest male medication-assisted treatment men neural neural circuit neurobiological mechanism neuroimaging novel opioid use pharmacologic psychologic randomized placebo-controlled clinical trial relapse prevention response sex social social relationships tool

项目摘要

Project Summary The proposed project is a new submission by a New and Early Stage Investigator for an R01 (PAR-19-384). Social connection with close others is a fundamental human need. Feeling connected to others reliably and robustly predicts health and wellbeing whereas feeling disconnected or isolated from others negatively impacts health. Less well understood, however, are the processes by which subjective feelings of social connection are maintained over time. Consistent with long-standing animal models dating back to the 1970’s, recent experimental work in humans has shown that opioids contribute to social connection with close friends, romantic partners, and family. Specifically, naltrexone, a common medication prescribed to assist in the recovery from addiction that blocks the action of naturally occurring opioids, unfortunately leads to a reduction in feelings of social connection toward close others in an otherwise healthy sample. These findings raise the possibility that the medication used to treat addiction may introduce an unintended barrier to one of the most effective contributors to long-term maintenance: close social relationships. Indeed, close social relationships and the feelings of ‘social connection’ within such relationships are major contributors to relapse prevention and one of the most valued tools for enhancing the effectiveness of medication-assisted treatment. Based on these findings, there has been a growing interest in whether opioid pathways contribute to feelings of social connection with close others in a causal manner and how these effects might occur. However, it remains surprising that the social psychological consequences of opioids and their contribution to social connection have not been more fully explored in humans. Therefore, the primary objective of this project is to conduct a novel experimental manipulation in humans to clarify the causal role of opioids in (1) daily, naturalistic feelings of social connection outside of the laboratory, (2) the neural signatures of feelings of social connection, and (3) feelings of social connection in response to personalized experiences with friends and family using standardized laboratory tasks. For these purposes, we propose targeting a sample of 210 young, healthy adults on a multi-method randomized placebo-controlled clinical trial. Additional exploratory aims will examine whether naltrexone induced changes in daily feelings of social connection predict variation in neural responding to social tasks, and whether naltrexone differently affects feelings of social connection in women and men. The proposal will link pharmacological mechanisms with neuroimaging parameters of brain function and affective social experience both outside of the laboratory and in the laboratory setting. We therefore anticipate that this study will contribute to new fundamental knowledge of the neurobiological pathways underlying the maintenance of social connection with implications for the treatment of opioid addiction.

项目摘要拟议的项目是R01（Par-19-384）的新的和早期调查员的新提交。与亲密他人的社会联系是人类的根本需求。感觉与他人相连并坚固地预测健康和福祉，而感觉与他人脱节或隔离影响健康。然而，不太了解的是社会主观感觉的过程随着时间的推移保持连接。与可以追溯到1970年代的长期动物模型一致，人类的最新实验工作表明，阿片类药物有助于与亲密朋友的社会联系，浪漫的伴侣和家人。具体而言，纳曲酮是一种常见药物，用于协助从成瘾中恢复，阻止了自然发生的阿片类药物的作用在与其他健康样本中关闭他人的社会联系中。这些发现提出了用来治疗成瘾的药物可能会引入意想不到的障碍长期维护的有效贡献者：紧密的社会关系。确实，紧密的社会关系这种关系中的“社交联系”的感觉是预防救济的主要因素这是增强药物辅助治疗有效性的最有价值的工具之一。基于这些发现，对阿片类药物途径是否有助于社会感，人们越来越感兴趣以因果方式与亲密的联系以及这些影响如何发生。但是，它仍然是令人惊讶的是，阿片类药物的社会心理后果及其对社会联系的贡献在人类中还没有得到更充分的探索。因此，该项目的主要目的是进行人类中的新型实验操作，以阐明阿片类药物在（1）每日自然主义感觉中的因果作用实验室之外的社会联系，（2）社会联系感的神经签名，（3）与朋友和家人的个性化经历一起使用社交联系的感觉标准化实验室任务。为了这些目的，我们提出针对210个年轻，健康的样本成年人进行了多方法随机安慰剂对照临床试验。其他探索目的将检查 Naltrexone是否引起社会联系日常感觉的变化可以预测中性的变化响应社会任务，以及纳曲酮对女性的社会联系感的影响是否不同和男人。该提案将将药理学机制与大脑功能的神经成像参数联系起来以及在实验室和实验室环境之外的情感社会经验。因此，我们预计这项研究将有助于神经生物学途径的新基本知识维持社会联系的基础，对oid成瘾的治疗产生了影响。