Inflammation and Innate Immunity Research Cluster

炎症和先天免疫研究集群

• 批准号: 7359463
• 负责人: Joel N Kline
• 金额: $ 2.89万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7359463
• 关键词: Agriculture; Animals; Area; Bacteria; Biology; Breathing; Development; Discipline; Disease; Endotoxins; Environmental Exposure; Environmental Health; Environmental Pollution; Environmental Risk Factor; Epithelial; Farming environment; Goals; Health; Histamine; Home environment; Hygiene; Immune; Immune response; Immune system; Immunology; Inflammation; Inflammatory; Investigation; Link; Lung diseases; Microbial Biofilms; Natural Immunity; Permeability; Population; Predisposition; Property; Recording of previous events; Research; Resources; Respiratory physiology; Response Elements; Risk; Role; Rural; Sarcoidosis; Science; Training; Work; airway inflammation; allergic airway inflammation; atopy; beta-Defensins; environmental agent; member; microbial; response

Rationale and Aims The Inflammation and Innate Immunity Research Cluster serves as the intellectual home for EHSRC members whose research is focused on mechanisms of immune responses. Although the expertise of many of its members is centered on airway inflammation, others focus on innate mechanisms relevant to systemic or more generally applicable immune responses. Some of these studies are directly linked with environmental exposures (e.g. transduction of the effects of endotoxin inhalation; environmental risk factors for systemic disorders such as sarcoidosis), whereas others relate to modulation of innate immune responses (e.g. the properties of beta-defensins and other innate immune response elements; effects of histamine on airway epithelial permeability) or host susceptibility to environmentally encountered agents (e.g. the role of biofilms in modulating response to inhaled bacteria). The research cluster members have a long history of investigations in basic airway and inflammation biology, and have been responsible for an important body of work that has advanced our understanding of how innate immune system responses modulate the effects of environmental agents, such as microbial products. These products have an important effect on rural and environmental health, and they have been implicated in the development of both adverse health consequences (for example, progressive accelerated decline of respiratory function among workers occupationally exposed in animal confinement facilities) and protective responses (for example, as codified in the hygiene hypothesis, the reduced risk of atopy and allergic airway inflammation among those raised on a farm). The goals of the Inflammation and Innate Immunity Research Cluster are to enhance the development of new science related to environmental lung disease, and to promote the use of research findings to reduce the adverse health effects of environmental contaminants among rural and agricultural populations. The aims of the Cluster are to: Aim 1) Promote investigations into inflammatory and immune mechanisms relevant to and responsible for the health effects of agricultural and rural exposures; Aim 2) Promote and enhance training in the disciplines of inflammation and immunology that are relevant to environmentally-related lung disease; encourage trainees to pursue studies in related areas of research; Aim 3) Serve as a national resource in inflammation and immunology for mechanistic studies related to agricultural and rural exposures.

理由和目标 炎症和先天免疫研究集群是EHSRC的知识之家 其研究重点是免疫反应机制的成员。虽然专业知识 其许多成员以气道炎症为中心，其他成员则关注与 全身性或更普遍适用的免疫反应。其中一些研究直接与 环境暴露（例如，内毒素吸入效应的传导;环境风险因素 对于全身性疾病如结节病），而其他涉及先天免疫调节， 反应（例如β-防御素和其他先天免疫反应元件的性质; 组胺对气道上皮通透性）或宿主对环境中遇到的物质的敏感性 (e.g.生物膜在调节对吸入细菌的反应中的作用）。研究组成员有一个 在基础气道和炎症生物学方面有着悠久的研究历史， 这是一项重要的工作，它促进了我们对先天免疫系统如何反应的理解。 调节环境因素的影响，如微生物产品。这些产品具有 对农村和环境健康的重要影响，并与发展 这两种不利的健康后果（例如，呼吸功能的进行性加速下降 在动物圈养设施中职业暴露的工人）和保护性反应（ 例如，正如卫生假说所编纂的那样，特应性和过敏性气道炎症的风险降低 在农场长大的人）。炎症和先天免疫研究组的目标是 加强与环境肺病有关的新科学的发展，并促进使用 研究结果，以减少环境污染物对农村和 农业人口。该小组的目标是： 目的1）促进对与以下疾病相关并负责的炎症和免疫机制的研究： 农业和农村暴露对健康的影响; 目标2）促进和加强与以下方面有关的炎症和免疫学学科的培训： 与环境有关的肺部疾病;鼓励学员在 调查研究; 目标3）作为炎症和免疫学的国家资源，用于与以下相关的机制研究： 农业和农村风险。