Facility Core A--Integrative Health Sciences

综合健康科学设施是环境健康的一个新的授权组成部分 科学核心中心拨款计划。它代表了NIEHS在促进和支持 翻译和临床研究“，以更好地了解环境暴露对 虽然这是一项新的要求，但这种对人类研究的重视已经是一个长期存在的 爱荷华大学EHSRC的实力。克莱恩医生最初是由大卫医生带进中心的 施瓦茨将领导对人类受试者对常见农村和农业环境的反应的研究 暴露；需要基础设施以安全地进行这种研究(对两个研究对象 和研究人员)、可重复性和严格的科学方法导致了临床 暴露设施(由爱荷华州大学和医学院资助)，包括 关键能力。自从临床暴露设施的发展以来，我们已经扩大了该设施的 焦点，支持放射成像、支气管镜检查和其他所需的服务，以翻译基本的 对临床研究的调查。简而言之，我们开发了一个综合健康科学设施，如 在最新的环境健康科学核心中心资助RFA中描述了这一点。因此，在这股潮流中， 申请，我们报告(以前命名的)临床暴露设施核心的进展情况，以及 描述我们对(未来指定的)综合健康科学设施的计划。

The Integrative Health Sciences Facility is a newly mandated component of the Environmental Health Sciences Core Center Grants program. It represents the interest of the'NIEHS in promoting and supporting translational and clinical research studies "to better understand the impact of environmental exposures on human disease." Although a new requirement, this emphasis on human studies has been a long-standing strength of the University of Iowa EHSRC. Dr. Kline was initially brought into the Center by Dr. David Schwartz to lead studies, in human subjects, of the responses to common rural and agricultural environmental exposures; the need for infrastructure to conduct such studies with safety (to both research subjects and investigators), reproducibility, and rigorous scientific approaches led to the development of the Clinical Exposure Facility (construction funded by the University of Iowa and the College of Medicine), with these critical capabilities. Since the Clinical Exposure Facility's development, we have expanded the Facility's focus, supporting radiological imaging, bronchoscopies, and other services needed to translate basic investigations into clinical studies. In short, we have developed an Integrative Health Sciences Facility, as described in the most recent Environmental Health Sciences Core Center Grants RFA. Thus, in this current application, we report on the progress of the (previously named) Clinical Exposure Facility Core, and describe our plans for the (future designation) Integrative Health Sciences Facility.