CORE--RADIOIMMUNOASSAY/MONOCLONAL ANTIBODIES

核心--放射免疫分析/单克隆抗体

• 批准号: 7550755
• 负责人: PATRICK SLUSS
• 金额: $ 9.99万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7550755
• 关键词: Animal Model; Animals; Antibodies; Arts; Basic Science; Biological Assay; Biological Markers; Budgets; Clinical; Clinical Investigator; Clinical Trials; Databases; Defect; Development; Diabetes Mellitus; Functional disorder; Generations; Genetic; Human; Immunoassay; Incidence; Insulin; Laboratories; Link; Measurement; Measures; Methods; Mission; Monoclonal Antibodies; Mus; Numbers; Peptides; Physiology; Plasma; Proteins; Publications; Radioimmunoassay; Range; Rattus; Reagent; Research Personnel; Serum; Services; Site; Speed; System; Testing; Translating; base; experience; glucagon-like peptide 1; human disease; innovation; member; metabolic abnormality assessment; novel

In its broadest mission, the Immunoassay Core provides technical support and services for the application and innovation of immunoassays. These activities serve as a critical link between basic and clinical investigators. Members of BADERC can access state-of-the-art commercial immunoassays for measuring a wide range of analytes. Many of these are fully automated, high speed systems that can support very large testing volumes and multi-site studies. Importantly, the Immunoassay Core is experienced in adapting these systems to measurements using animal serum or plasma (rats and mice.) The Core also provides access to radioimmunoassay that has been established for many years in Dr Habener's laboratory for metabolic studies in animals and humans. Access to well validated and standardized assays provides interpretive power based upon large normative and pathophysiologic databases thus serving as a crucial backdrop for clinical investigations. The effort to translate basic research into clinical advances benefits by our ability to expedite the transfer of newly identified biomarkers into novel assays that meet the need for the high volume, precise, and sensitive clinical measurements needed to objectively assess the value of new biomarkers. As investigators increasingly focus upon the genetic basis of human disease, an effective mechanism is needed to provide the requisite analytic methods to characterize phenotypic correlates and to assess the incidence of specific genetic-based defects in clinical (e.g., human) and animal models. The Immunoassay Core provides monoclonal facilities and expertise in the generation of antibodies for immunoassay and reagents.

在其最广泛的使命中，免疫测定核心为世界卫生组织提供技术支持和服务