Molecular Software and Hardware for Programmed Chemical Synthesis

用于程序化化学合成的分子软件和硬件

• 批准号: EP/F056605/1
• 负责人: Andrew Turberfield
• 金额: $ 17.62万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF056605%2F1
• 关键词: Molecular; Software; Hardware; Programmed; Chemical

We intend to design a nanoscale chemical factory in which the machines, like the products, are molecules. The factory will not only build molecules but will be capable of evolving them to have desirable properties. The products will be linear molecules produced by linking together smaller building blocks in a defined sequence - at each stage the molecular machinery will be capable of choosing the correct building block from a range of possibilities. The system will be capable of synthesizing a library of molecules with different sequences and selecting 'successful' molecules for their fitness to perform a specified task. We will also develop designs for more powerful systems in which the molecular machinery responsible for chemical synthesis has internal computing power and can direct its own operation.

我们打算设计一个纳米级的化学工厂，其中的机器，就像产品一样，是分子。该工厂不仅能制造分子，还能将它们进化成具有理想特性的分子。产品将是线性分子，通过将较小的构建块以确定的顺序连接在一起而产生-在每个阶段，分子机器将能够从一系列可能性中选择正确的构建块。该系统将能够合成一个具有不同序列的分子库，并选择“成功”的分子来执行特定的任务。我们还将设计更强大的系统，其中负责化学合成的分子机器具有内部计算能力，可以指导自己的操作。

项目成果

The Evolution of DNA-Templated Synthesis as a Tool for Materials Discovery.

• DOI: 10.1021/acs.accounts.7b00280
• 发表时间: 2017-10-17
• 期刊: Accounts of chemical research
• 影响因子: 18.3
• 作者: O'Reilly RK;Turberfield AJ;Wilks TR
• 通讯作者: Wilks TR

A clocked finite state machine built from DNA.

• DOI: 10.1039/c2cc37227d
• 发表时间: 2013-01
• 期刊: Chemical communications
• 影响因子: 4.9
• 作者: Cristina Costa Santini;J. Bath;A. Tyrrell;A. Turberfield

DNA walker circuits: computational potential, design, and verification

• DOI: 10.1007/s11047-014-9426-9
• 发表时间: 2015-06-01
• 期刊: NATURAL COMPUTING
• 影响因子: 2.1
• 作者: Dannenberg, Frits;Kwiatkowska, Marta;Turberfield, Andrew J.
• 通讯作者: Turberfield, Andrew J.