Core B

核心B。交互验证核心（IVC） 导演：Chris Aiken，PhD 上述对核心A的生物信息学分析将大大改进候选相互作用的列表 HIV-1蛋白和细胞靶点之间的关系。但 结构分析的目标选择应基于已证明的功能相关性， HIV-1发病机制的相互作用。IVC将在PCHPI中发挥两个关键作用。首先，IVC将通知 通过鉴定那些在HIV感染者中表现出功能性后果的靶标来选择结构分析的靶标 细胞其次，IVC将测试由结构数据产生的特定假设，这些数据来自 PCHPI和该计划资助的其他潜在中心。因此，IVC将有助于整合 PCHPI通过在整个过程的早期和后期发挥关键作用。

Core B. Interactions Validation Core (IVC) Director: Chris Aiken, PhD The bioinformatics analyses described above for Core A will greatly refine the list of candidate interactions between HIV-1 proteins and cellular targets from that currently available in the public databases. However, the choice of targets for structural analysis should be based on demonstrated functional relevance of the interactions for HIV-1 pathogenesis. The IVC will play two key roles in the PCHPI. First, the IVC will inform the choice of targets for structural analysis by identifying those that exhibit functional consequences in HIVinfected cells. Second, the IVC will test specific hypotheses generated by the structural data that emerge from the PCHPI and potentially other Centers funded by the program. Thus, the IVC will serve to integrate the PCHPI by playing key roles at both early and late stages of the overall process.