Understanding Repetitive Behavior in Autism

了解自闭症患者的重复行为

• 批准号: 7293342
• 负责人: JAMES MCCRACKEN
• 金额: $ 28.87万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-06 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7293342
• 关键词: Adolescence; Adolescent; Advisory Committees; Affinity; Alleles; Anterior; Autistic Disorder; Basal Ganglia; Behavior; Behavioral; Biology; Brain; Brain Mapping; Brain imaging; Brain region; California; Charge; Child; Childhood; Clinical; Clinical Trials; Collaborations; Collection; Communities; Complex; Consult; Consultations; Corpus striatum structure; Data; Data Set; Databases; Decision Making; Development; Disease; Echo-Planar Imaging; Elements; Faculty; Follow-Up Studies; Fostering; Functional Magnetic Resonance Imaging; Functional disorder; Future; Generations; Genes; Genetic; Genotype; Haplotypes; Image; Impairment; Individual; Institutes; Intervention; Investigation; Language; Learning; Light; Link; Magnetic Resonance Imaging; Measures; National Institute of Mental Health; Nature; Neurobiology; Neurology; Neurons; Numbers; Pharmaceutical Preparations; Phenotype; Pilot Projects; Placebos; Prefrontal Cortex; Process; Psychiatry; Quality Control; Rate; Recruitment Activity; Relative (related person); Research; Research Design; Research Personnel; Resources; Risk; Risperidone; Sampling; Scanning; Science; Series; Site; Social Behavior; Speed; Stereotyping; Stimulus; Subgroup; System; Testing; Therapeutic; Time; Treatment Effectiveness; Ventral Striatum; Week; Work; atypical antipsychotic; autism spectrum disorder; base; biobehavior; data management; experience; family genetics; hemodynamics; indexing; interest; lectures; medical schools; member; neural circuit; neuroimaging; neuropsychiatry; professor; programs; relating to nervous system; response; stereotypy

the organizational framework, decision-making process for the use of the cores, and plans for quality control are discussed in much greater detail in the 25-page core descriptions furnished below. CORE A: ADMINISTRATIVE/DATA MANAGEMENT CORE Staff: The Administrative/Data Management Core will be directed by Dr. Marian Sigman and Dr. Daniel Geschwind. Dr. Sigman has been Prinicipal Investigator of the UCLA Collaborative Program of Excellence for 9 years and the UCLA STAART for 3 years. Dr. Geschwind is Director of the Clinical Program in Autism at UCLA. They will be assisted by an Executive Committee composed of the Project and Core Pis and will consult with the Internal Advisory Committee, the Community Advisory Committee, and the External Advisory Committee when this is formed. The Data Management Director is Dr. Jeanette Papp who is the director of the UCLA Sequencing and Genotyping Facility. Dr. Papp has been in charge of the data management over the course of the last three years for the STAART Center. Aims of the Administrative/Data Management Core: Core A, the Administrative/Data Management Core, provides an organizational framework for coordination and integration of resources and activities as well as providing data management and analytical support so as to handle data entry, checking, and sharing with the planned National Database for Autism Research (NDAR). Major decisions about the proposed UCLA ACE will be made by the Executive Committee after consultation with the three Advisory Committees described below. The Internal Advisory Committee will also be used to fulfill the responsibilities of a local DSMB. In addition, the UCLA Administrative/Data Management Core is responsible for two unique programs that have been instituted at UCLA: the monthly Affinity lecture series and the pilot project program. These programs are described in more detail in the expanded descriptions below. CORE B: THE IMAGING CORE Staff: The Brain Imaging Core will be directed by Dr. Susan Bookheimer. Dr. Bookheimer has been a member of the UCLA Brain Mapping Faculty since 1993. She has worked in brain imaging for 17 years and has been active in MR imaging since the inception of functional MRI in the early 1990s. She is an expert in pediatric imaging and through the CPEA network, has been imaging children with autism for 8 years. She will be aided by Dr. Mark Cohen and Dr. Mirella Dapretto. Dr. Cohen is a Professor of Neurology, of Radiological Sciences and of Psychiatry and Biobehavioral Sciences at the UCLA School of Medicine. He is an internationally recognized expert in high-speed magnetic resonance imaging and its applications, particularly in the use of ultra-fast echo-planar imaging for the collection of brain activation data sets, and he has been active in the development of functional magnetic resonance imaging since its inception. Dr. Dapretto is an Associate Professor in the UCLA Brain Mapping Center and has worked with Dr. Bookheimer for 10 years on pediatric neuroimaging. She has ample experience in scanning children with autism; as part of our long-standing CPEA fMRI project Drs.Bookheimer and Dapretto have scanned nearly 200 children with autism and several times that number of typically developing children. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 272

组织框架、使用核心的决策过程以及 质量控制在下面提供的25页核心描述中有更详细的讨论。 核心A：行政/数据管理核心 工作人员： 管理/数据管理核心将由Marian Sigman博士和丹尼尔Geschwind博士指导。 博士Sigman担任加州大学洛杉矶分校卓越合作计划的首席研究员已有9年， UCLA STAART三年Geschwind博士是加州大学洛杉矶分校自闭症临床项目主任。他们将 由项目和核心PI组成的执行委员会协助，并与内部 咨询委员会、社区咨询委员会和外部咨询委员会， 形成了数据管理总监是Jeanette Papp博士，她是加州大学洛杉矶分校测序总监， 基因分型设施。Papp博士在过去三年中一直负责数据管理 多年来，为中心。 行政/数据管理核心的目标： 核心A，即行政/数据管理核心，为协调和 整合资源和活动，并提供数据管理和分析支持， 处理数据输入，检查，并与计划中的国家自闭症研究数据库（NDAR）共享。 关于拟议的UCLA ACE的主要决定将由执行委员会在咨询后作出 与下文所述的三个咨询委员会合作。内部咨询委员会还将用于 履行当地DSMB的职责。此外，UCLA行政/数据管理核心是 负责两个独特的计划，已在加州大学洛杉矶分校设立：每月亲和力讲座系列和 试点项目方案。这些程序在下面的扩展描述中有更详细的描述。 核心B：成像核心 工作人员： 大脑成像核心将由Susan Bookheimer博士指导。布克海默博士一直是 UCLA Brain Mapping Faculty自1993年以来她在脑成像领域工作了17年， 自20世纪90年代初功能磁共振成像问世以来，磁共振成像。她是儿科影像学专家， 通过CPEA网络，已经对自闭症儿童进行了8年的成像。 她将得到马克·科恩博士和米雷拉·达普雷特博士的帮助。科恩博士是神经病学教授， 加州大学洛杉矶分校医学院放射科学系和精神病学与生物行为科学系。他是一 国际公认的高速磁共振成像及其应用专家，特别是在 使用超快速回波平面成像收集大脑激活数据集，他一直积极 在功能性磁共振成像的发展中发挥了重要作用。Dr. Dapretto是一名律师 教授在加州大学洛杉矶分校脑映射中心，并已与博士布克海默10年的儿科 神经成像她在扫描自闭症儿童方面有丰富的经验;作为我们长期CPEA的一部分， fMRI项目Bookheimer博士和Dapretto博士对近200名自闭症儿童进行了多次扫描 正常发育的孩子的数量 PHS 398/2590（2004年9月修订，2006年4月重新印发）第272页