Exploration of the use of 1,2-Diamines in Fused Heterocycle Synthesis: An Opportunity for Array Synthesis.

探索 1,2-二胺在稠合杂环合成中的应用：阵列合成的机会。

• 批准号: EP/F068344/1
• 负责人: James Anderson
• 金额: $ 44.01万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF068344%2F1
• 关键词: Exploration; use; Diamines; Fused; Heterocycle

Molecules containing rings of carbon and nitrogen atoms are prevalent in many biologically active molecules, dyes and new materials. In particular a large proportion of medicines contain this structural element. We propose to investigate the use of a straight chain molecule containing two nitrogen atoms, which upon cyclisation onto itself will give two different sorts of ring compounds, each containing a different one of the two nitrogen atoms. We aim to find conditions which control this cyclisation so we can make either cyclic form at will. We have already invented an efficient way of preparing the straight chain molecules containing two nitrogen atoms and we want to use these unique structures to make a large variety of unique ring compounds. These novel ring compounds can be made even more diverse by starting with more complex starting materials which we use to make the straight chain compounds from. In particular we want to investigate the addition of carbon containing groups to the reaction that prepares the straight chain molecules. The preparation of a large selection, an array, of ring compounds will be developed in industry by techniques that are efficient in time and resources, to give promising drug candidates for medicine.

含有碳和氮原子环的分子普遍存在于许多生物活性分子、染料和新材料中。特别是，很大比例的药品含有这一结构性因素。我们建议研究含有两个氮原子的直链分子的使用，当它自身循环时，将得到两种不同类型的环化合物，每个环化合物包含两个氮原子中的不同一个。我们的目标是找到控制这种循环的条件，这样我们就可以随意地制作任何一种循环形式。我们已经发明了一种有效的方法来制备含有两个氮原子的直链分子，我们想利用这些独特的结构来制造各种独特的环化合物。通过从更复杂的起始材料开始，这些新型的环化合物可以变得更加多样化，我们使用这些原料来制造直链化合物。特别是，我们想要研究在制备直链分子的反应中添加含碳基团。大量环状化合物的制备将在工业上通过在时间和资源上高效的技术来开发，以提供有希望的药物候选药物。