Exploration of the use of 1,2-Diamines in Fused Heterocycle Synthesis: An Opportunity for Array Synthesis.

含有碳和氮原子环的分子在许多生物活性分子、染料和新材料中普遍存在。特别是大部分药物含有这种结构元素。我们建议研究使用含有两个氮原子的直链分子，其在环化到自身上时将产生两种不同类型的环化合物，每种环化合物含有两个氮原子中的不同的一个。我们的目标是找到控制这种环化的条件，这样我们就可以随意制造任何一种环状形式。我们已经发明了一种制备含有两个氮原子的直链分子的有效方法，我们希望利用这些独特的结构来制备各种各样的独特的环化合物。这些新颖的环状化合物可以通过从我们用来制造直链化合物的更复杂的起始材料开始而变得更加多样化。特别地，我们想要研究在制备直链分子的反应中添加含碳基团。工业上将通过在时间和资源上有效的技术来开发大量选择的环状化合物阵列的制备，以提供有希望的药物候选物。

Molecules containing rings of carbon and nitrogen atoms are prevalent in many biologically active molecules, dyes and new materials. In particular a large proportion of medicines contain this structural element. We propose to investigate the use of a straight chain molecule containing two nitrogen atoms, which upon cyclisation onto itself will give two different sorts of ring compounds, each containing a different one of the two nitrogen atoms. We aim to find conditions which control this cyclisation so we can make either cyclic form at will. We have already invented an efficient way of preparing the straight chain molecules containing two nitrogen atoms and we want to use these unique structures to make a large variety of unique ring compounds. These novel ring compounds can be made even more diverse by starting with more complex starting materials which we use to make the straight chain compounds from. In particular we want to investigate the addition of carbon containing groups to the reaction that prepares the straight chain molecules. The preparation of a large selection, an array, of ring compounds will be developed in industry by techniques that are efficient in time and resources, to give promising drug candidates for medicine.