Alcohol and Colorectal Cancer: The Influence of Inherited and Nutritional Factors
酒精和结直肠癌:遗传和营养因素的影响
基本信息
- 批准号:7512389
- 负责人:
- 金额:$ 20.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdverse effectsAffectAlcohol consumptionAlcoholsAreaBetaineBiochemical ReactionBiologicalBlood specimenCancer EtiologyCarbonCerealsCessation of lifeCholineCollaborationsColon CarcinomaColorectalColorectal AdenomaColorectal CancerDNADNA biosynthesisDNA chemical synthesisDataData SetDatabasesDevelopmentDietary FactorsDietary intakeDoseEatingEpidemiologic StudiesEpidemiologyEvaluationFamily history ofFirst Degree RelativeFolateFolic AcidFollow-Up StudiesFoodGenotypeHandHealth ProfessionalIncidenceIndividualInheritedIntakeInterdisciplinary StudyKnowledgeLinkMalignant NeoplasmsMetabolismMethionineMethylationMethylenetetrahydrofolate reductase (NADPH)NatureNurses&apos Health StudyNutrientNutritionalOutcomeOxidoreductaseParentsPathway interactionsPatternPopulationPrevention GuidelinesProspective StudiesPublic HealthReaction TimeRecording of previous eventsResearchResearch PersonnelResourcesRiskRisk FactorsRoleScientistSiblingsSourceTimeVariantVitamin B6WomanWorkalcohol epidemiologyalcohol researchanticancer researchcancer preventioncancer riskcarbenecarcinogenesiscase controlcostcost effectivedrinkingfolic acid metabolismfollow-upfortificationgenetic risk factorinsightinterestlifetime riskmenmethyl groupnovelnutritional epidemiologyresponsetumortumor initiation
项目摘要
DESCRIPTION (provided by applicant): Alcohol consumption is an established risk factor for colorectal cancer. However, it is not clear what the biological mechanisms are and if there are susceptible sub-populations. Building on the initial finding that a positive association between alcohol intake and colon cancer was largely restricted to women with a positive family history of colorectal cancer, we propose to characterize the dose-response and timing of the association to examine the modifying role of inherited factors in relation to colorectal adenoma and colorectal cancer risk. If alcohol operates through the one-carbon metabolism pathways, it is plausible that the influence of alcohol intake on colorectal carcinogenesis may have weakened after folate fortification of grain products, which was largely in place since 1996. Because most epidemiologic studies on alcohol and colorectal adenoma/cancer have been conducted in populations with follow-up prior to folate fortification, we propose to evaluate whether the association between alcohol and colorectal adenoma/cancer would be as strong as post fortification. Even if the overall association is weakened after the fortification, the positive association between alcohol consumption and colorectal adenoma/cancer may still persist among particularly susceptible populations. Those with family history of colorectal cancer may be one of the susceptible populations. Other susceptible populations include those with methylene-tetrahydrofolate reductase (MTHFR) 677 variant genotype and those with low intake of other nutrients involved in one-carbon metabolism, including vitamins B6 and B12, methionine, choline, and betaine. We have large prospective studies of women and men with existing data on alcohol consumption and drinking pattern and over 6,000 colorectal adenoma and about 2,800 colorectal cancer cases to address these scientific hypotheses in an extremely time- and cost- effective manner. This study may provide better insight on the nature of family history and provide useful cancer prevention guideline for the highly susceptible population of those with a family history. This proposed work will also provide opportunities for the first epidemiologic evaluation of alcohol and colorectal cancer risk by folate fortification status, which will clarity the involvement and importance of alcohol on one-carbon metabolism and determine the effect of alcohol consumption on colorectal cancer in current high-folate intake status.
Public Health Relevance: In this proposed work, we intend to explore the influence of inherited and dietary factors on the association between alcohol consumption and colorectal adenoma/cancer in large epidemiological studies of women and men. By clarifying the role of these factors on alcohol and colorectal cancer risk, this study can help identifying populations susceptible to the adverse effect of alcohol and guiding people in cancer prevention.
描述(由申请人提供):饮酒是结直肠癌的既定危险因素。然而,目前还不清楚其生物学机制是什么,也不清楚是否存在易感亚群。根据最初的发现,酒精摄入与结肠癌之间的正相关主要限于有结直肠癌阳性家族史的女性,我们建议表征这种关联的剂量-反应和时机,以检验遗传因素对结直肠癌腺瘤和结直肠癌风险的调节作用。如果酒精通过一碳代谢途径发挥作用,那么在谷物产品叶酸强化后,酒精摄入对结直肠癌发生的影响可能已经减弱,这在很大程度上是从1996年开始实施的。由于大多数关于酒精和结直肠腺瘤/癌症的流行病学研究都是在叶酸强化之前进行随访的人群中进行的,我们建议评估酒精与结直肠腺瘤/癌症之间的联系是否会像强化叶酸后一样强烈。即使在强化措施后总体关联性被削弱,饮酒与结直肠腺瘤/癌症之间的正相关性在特别敏感的人群中仍可能持续存在。有结直肠癌家族史的人可能是易感人群之一。其他易感人群包括具有亚甲基四氢叶酸还原酶(MTHFR)677变异基因的人群,以及那些摄入与一碳代谢有关的其他营养物质较少的人群,包括维生素B6和B12、蛋氨酸、胆碱和甜菜碱。我们对女性和男性进行了大型前瞻性研究,现有的饮酒和饮酒模式数据以及超过6,000例结直肠腺瘤和大约2,800例结直肠癌病例,以极具时间和成本效益的方式解决这些科学假设。这项研究可能会更好地了解家族史的性质,并为有家族史的高危人群提供有用的癌症预防指南。这项拟议的工作还将提供首次通过叶酸强化状态对酒精和结直肠癌风险进行流行病学评估的机会,这将澄清酒精对一碳代谢的参与和重要性,并确定在当前高叶酸摄入状态下酒精消费对结直肠癌的影响。
公共卫生相关性:在这项拟议的工作中,我们打算在女性和男性的大型流行病学研究中,探索遗传和饮食因素对饮酒与结直肠腺瘤/癌症之间关系的影响。通过澄清这些因素对酒精和结直肠癌风险的作用,这项研究可以帮助识别易受酒精不良影响的人群,并指导人们预防癌症。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
EUNYOUNG CHO其他文献
EUNYOUNG CHO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('EUNYOUNG CHO', 18)}}的其他基金
Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
膳食甲基评分、基因组 DNA 甲基化与结直肠癌
- 批准号:
7731861 - 财政年份:2009
- 资助金额:
$ 20.72万 - 项目类别:
Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
膳食甲基评分、基因组 DNA 甲基化与结直肠癌
- 批准号:
8071180 - 财政年份:2009
- 资助金额:
$ 20.72万 - 项目类别:
Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
膳食甲基评分、基因组 DNA 甲基化与结直肠癌
- 批准号:
8267118 - 财政年份:2009
- 资助金额:
$ 20.72万 - 项目类别:
Alcohol and Colorectal Cancer: The Influence of Inherited and Nutritional Factors
酒精和结直肠癌:遗传和营养因素的影响
- 批准号:
7677513 - 财政年份:2008
- 资助金额:
$ 20.72万 - 项目类别:
Metabolic and Epidemiologic Evaluation of Choline and Betaine Intake
胆碱和甜菜碱摄入量的代谢和流行病学评估
- 批准号:
7476484 - 财政年份:2007
- 资助金额:
$ 20.72万 - 项目类别:
Metabolic and Epidemiologic Evaluation of Choline and Betaine Intake
胆碱和甜菜碱摄入量的代谢和流行病学评估
- 批准号:
7320818 - 财政年份:2007
- 资助金额:
$ 20.72万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 20.72万 - 项目类别:
Research Grant