Arts, Research, T-cells & Socio-demographics (ARTS) in the Niagara Region

说明(由申请人提供)：参与临床和预防研究的少数族裔和低收入个人人数过少，对科学成果的代表性产生重大影响，并导致社会和临床不公正。罗斯韦尔公园癌症研究所(RPCI)和尼亚加拉瀑布社区成员正在创建权力中立的合作，以满足脆弱社区的需求，以减少癌症差异和改善癌症研究。拟议的“ARTS”(艺术、研究、T细胞和社会人口学)研究创造了一个合作机会，将收入相对较低的多元化人口与NCI综合癌症中心联系起来，以测试研究各种促成因素(如社会人口学因素，包括贫困和种族/民族)与健康差距(如免疫功能、癌症风险)之间关系的可行性。这项研究的目标是研究如何让尼亚加拉瀑布地区的居民与RPCI的科学家一起参与，以增进彼此的了解和参与癌症预防研究，并获得有关Treg细胞水平变化的初步数据。为实现这一目标提出了以下具体目标：目标1.通过以社区为基础的创造性方法和尼亚加拉艺术文化中心(NACC)内的干预措施，通过出席、调查和参与研究来衡量，调查教育和招募尼亚加拉瀑布居民进行癌症预防研究的可行性。目的2.探讨以社区为基础的干预方法进行流行病学调查采集、生物标本采集和调节性T细胞检测的技术可行性。目标3.制定一个有意义的适当框架和最佳方法，以便在所有学术和社区合作伙伴和参与者之间分享社会和生物数据的研究结果。通过NACC的教育招聘计划，将使用社区友好的受众响应系统(ARS)收集人口统计数据、情感指标(例如，人们与研究想法相关联的感觉)和参与意向。个人可以选择在不同的层面上参与，那些选择献血的人将使我们能够获得关于某些生活方式(例如吸烟、锻炼、饮食)和人口因素(例如收入、邻里关系、种族/民族)与由Treg细胞(可以阻止免疫系统保护身体的细胞)测量的健康居民免疫系统的重要方面之间的关系的试点数据。预计这项可行性研究的过程和结果结果将为与以下相关的研究问题提供试点数据：1)基于情感的决策因素对研究参与的作用；2)免疫指标与社会人口、环境和行为变量的关系的异质性；3)将医学研究教育和招募与专注于艺术的社区团体联系起来的有效性；以及4)研究机构和社区合作伙伴招募、积累和分析与癌症研究相关的措施所需的技术便利。

DESCRIPTION (provided by applicant): The disproportionately lower number of minority and low income individuals participating in clinical and prevention research has a significant impact on the representativeness of scientific outcomes and result in social and clinical injustices. Roswell Park Cancer Institute (RPCI) and Niagara Falls community members are creating power-neutral collaborations to meet the needs of vulnerable communities in order to reduce cancer disparities and improve cancer research. The proposed "ARTS" (Arts, Research, T-cells & Sociodemographics) study creates a collaborative opportunity linking a diverse, relatively low income population with an NCI Comprehensive Cancer Center to test the feasibility of studying the relationship among various contributing factors (e.g., socio-demographics, including poverty and race/ethnicity) to health disparities (e.g., immune function, risks for cancer). The goal of this study is to investigate strategies to engage residents in the Niagara Falls region with scientists at RPCI to increase mutual understanding of each other and participation in cancer prevention research, and to obtain pilot data on variations in Treg cell levels. The following Specific Aims are proposed to achieve this goal: Aim 1. Investigate the feasibility of educating and recruiting Niagara Falls residents to cancer prevention studies through creative community-based methods and interventions within the Niagara Arts & Cultural Center (NACC) as measured through attendance, surveys and study participation. Aim 2. Investigate the technical feasibility of epidemiological survey collection, biological specimen collection, and performing regulatory T Cell assays through community-based interventional methods. Aim 3. Develop a meaningful and appropriate framework and best methods for sharing findings from social and biological data among all academic and community partners and participants. Through educational recruitment programs based at the NACC, demographics, affective measures (e.g., the feeling people associate with the idea of research), and intent to participate, will be collected using a community-friendly audience response system (ARS). Individuals may choose to participate at various levels, and those selecting to donate blood will allow us to obtain pilot data about how certain lifestyle (e.g., smoking, exercise, diet) and demographic factors (e.g., income, neighborhood, race/ethnicity) are related to important aspects of the immune system in healthy residents as measured by Treg cells (cells that can prevent the immune system from protecting the body). It is expected that process and outcome results from this feasibility study will provide pilot data for research questions related to: 1) the role of affectively-based decision making factors on research participation; 2) heterogeneity of immunological indicators in relationship to socio-demographic, environmental, and behavioral variables; 3) the effectiveness of linking medical research education and recruitment with a community group focused on the arts; and 4) the technical accommodations necessary for a research institution and community partners to recruit, accrue, and analyze measures related to cancer research.