CORE -- AFTERCARE RESEARCH PROGRAM

善后研究计划是加州大学洛杉矶分校神经精神研究所的一个门诊研究诊所，将为参与该中心研究项目的首发患者提供招募，药理学和心理社会干预以及症状和功能结局评估的临床场所。善后计划的主要使命是提供一个结构化和高质量的临床护理环境，在此环境中，本中心的研究可以进行。善后研究计划将提供一个集中和标准化的过程，筛选和诊断首发精神分裂症患者的参与者，提供他们的临床服务，并完成症状，工作功能和社会功能的高质量纵向评估。如本核心预算说明部分所述，这种集中化将为多个国家节省大量资金， 与独立进行这些研究项目的成本相比，涉及善后方案患者的个别项目的成本。此外，通过利用一组共享的首发患者，将有机会在各个项目中进行综合数据分析。第二个功能是优化患者参与的水平， 中心相关研究项目。第三个功能是提供正常受试者的样本，人口统计学上与首次发作患者相当，用于潜在参与中心附属项目。善后护理研究计划的第四项功能，是为个别计划、诊断及症状评估核心小组及功能小组所制订的新措施提供一批方便的病人志愿者， 核心成果。第五个功能是为博士前和博士后研究员提供研究培训场所，以鼓励新的翻译研究人员的发展。两名精神科医生和三名硕士级治疗师将在加州大学洛杉矶分校医学广场分配给该计划的空间内提供临床干预和研究评估。

The Aftercare Research Program is an outpatient research clinic at the UCLA Neuropsychiatric Institute that will provide the clinical site for the recruitment, pharmacological and psychosocial interventions, and assessments of symptoms and functional outcome for first-episode patients who are participating in research projects in this Center. The primary mission of the Aftercare Program is to provide a structured and high quality clinical care setting within which this Center research can take place. The Aftercare Research Program will provide a centralized and standardized process for screening and diagnosing first-episode schizophrenia patient participants, providing their clinical services, and completing high-quality longitudinal assessments of symptoms, work functioning, and social functioning. As detailed in the budget justification section for this Core, this centralization will result in great savings to the multiple individual projects that involve Aftercare Program patients, compared to costs if these research projects were carried out independently. Furthermore, by utilizing a shared group of first-episode patients, opportunities for integrative data analyses across projects will become available. A second function is to optimize the level of patient participation in Center-related research projects. A third function is to provide a sample of normal subjects, demographically comparable to the first-episode patients, for potential participation in Center-affiliated projects. A fourth function of the Aftercare Research Program is to provide a convenient group of patient volunteers for the piloting of new measures being developed by individual projects and by the Diagnosis and Symptom Assessment Core and the Functional Outcome Core. A fifth function is to offer a research training site for predoctoral and post-doctoral research fellows to encourage development of new translational researchers. Two psychiatrists and three masters level therapists will provide the clinical interventions and research assessments in space allocated to the Program in the UCLA Medical Plaza.