Cognitive and Affective Dysfunctions in the Psychoses

描述（由申请人提供）：这个新的博士后临床研究培训计划侧重于培养专注于精神障碍中认知和情感功能障碍的研究科学家。该项目将采用一种培训模式，强调将认知科学和认知、社会和情感神经科学的概念和范式引入以患者为导向的、针对精神分裂症及相关精神病的神经认知、社会认知和情感核心缺陷的临床研究所需的技能。与临床研究者和认知科学家/神经科学家的直接指导互动将是这个项目的一个关键特点，重点是发展和实施与精神障碍患者和有这种疾病风险的人的临床研究。临床研究人员和认知科学家/神经科学家的共同指导将确保对精神障碍研究中使用的适应范式的原则和方法的理解的发展。该项目的其他培训主题将侧重于研究精神障碍中核心认知和情感功能障碍与功能结果之间的联系，以及研究精神分裂症和相关精神障碍的前驱期、首发期和慢性期的这些过程。新的培训计划将重点关注临床心理学、认知科学、认知神经科学或情感神经科学的博士学位，以及计划从事研究工作的精神病住院医师和医学博士。培训计划将包括(1)通过与共同导师的互动，在精神障碍的认知和情感功能障碍的转化临床研究的开发和实施方面进行广泛的实践培训，(2)每周一次的精神病研究研讨会，由临床研究人员和认知科学家/神经科学家共同授课，(3)每月一次的研究职业发展研讨会，(4)密集的区域职业发展静修，(5)课程作业。针对个人研究兴趣的研讨会和实验室培训，以及(6)负责任的研究行为培训。培训将与一些临床研究机会紧密结合，这些临床研究机会允许患有精神分裂症和相关精神障碍的研究参与者。

DESCRIPTION (provided by applicant): This new postdoctoral clinical research training program focuses on developing research scientists who focus on cognitive and affective dysfunctions in psychotic disorders. The program will utilize a training model that emphasizes the skills needed to bring concepts and paradigms from cognitive science and cognitive, social, and affective neuroscience into patient- oriented, clinical research on core deficits in neurocognition, social cognition, and emotion in schizophrenia and related psychoses. Direct mentoring interactions with both clinical investigators and cognitive scientists/neuroscientists wil be a key feature of this program, with the focus being on development and implementation of clinical research with individuals with psychotic disorders and those at risk for such disorders. Co-mentoring by clinical investigators and cognitive scientists/neuroscientists will ensure the development of an understanding of the principles and methods for adapting paradigms for use in research on psychotic disorders. Additional training themes of this program will be an emphasis on research on the links between core cognitive and affective dysfunctions and functional outcome in psychotic disorders and on research that examines these processes across prodromal, first episode, and chronic phases of schizophrenia and related psychotic disorders. The new training program will focus on individuals with Ph.D. in clinical psychology, cognitive science, cognitive neuroscience, or affective neuroscience, and on individuals with an M.D. followed by a psychiatric residency who plan to pursue a research career. The training program will include (1) extensive hands-on training in the development and implementation of translational clinical research on cognitive and affective dysfunctions in psychotic disorders through interactions with the co-mentors, (2) a weekly Research Seminar on the Psychosis taught jointly by clinical researchers and cognitive scientists/neuroscientists, (3) a monthly Research Career Development Seminar, (4) an intensive regional career development retreat, (5) coursework, workshops, and laboratory training tailored to individual research interests, and (6) training in responsible conduct of research. The training will be closely interfaced with a number of clinical research opportunities that allow access to research participants with schizophrenia and related psychotic disorders.