Clinical

临床核心(CC)的主要目标是提供患者访问和高质量的数据收集 包括定量放射学分析，以支持匹兹堡大学COPD的SCCOR。至 为了实现这些目标，拟议的研究将实现以下具体目标： A1.接触我们多样化的、有特色的患者群体，以有效地为项目招募受试者 1和4，并为项目2保持对组织的可访问性。 A2.为了成功地协助执行复杂的协议、数据收集和向 ITBC的核心。 A3.将定量计算机断层扫描应用于研究对象的表型特征 对慢性阻塞性肺疾病和疾病进展和结果的纵向评估。 此核心非常适合实现这些目标，因为它结合了协作者的优势和 过去受试者招募的生产力历史，以及临床、生理和定量的最新水平 射线照相表征。它将确保接触到3700名受试者的特征良好的队列 匹兹堡肺筛查研究(PLuSS)和肺气肿COPD研究中心(ECRC)及其 为7个NHLBI资助的临床研究合同做出贡献的良好记录。此外，它还将利用 不能使用NHLBI赞助的LTRC和匹兹堡大学组织的基础设施 资源以及非常积极的肺移植计划，以确保获得高质量的肺组织。 这一核心的第三个目标扩展了加州大学放射学研究小组的合作 匹兹堡和全身影像中心(Capture Centre)创建了一支具有国际影响力的部队 在定量成像领域享有盛誉，他们都是肖尔巴博士的长期合作伙伴。我们提出了一个 这个项目的临床研究人员和强大的成像团队之间的迭代互动。这个 项目1中提出的初步数据和临床核心中的扩展揭示了现有的结构 以及现有协作的实力，并确认此方法在满足 我们的目标是在项目1中创建一个新的COPD分类系统，并为 在疾病改进干预措施的背景下进行患者选择和结果评估，例如在我们的 项目4.

The primary objective of the Clinical Core (CC) is to provide patient access and quality data collection including quantitative radiologic analysis to support the SCCOR in COPD at the University of Pittsburgh. To achieve these objectives, the research proposed will accomplish the following specific aims: A1. To access our diverse well characterized patient populations to efficiently recruit subjects for Projects 1 and 4 and maintain accessibility to tissue for Project 2. A2. To successfully assist in the execution of complex protocols, data collection and transfer of data to the ITBC core. A3. To apply quantitative computed tomography to the phenotypic characterization of subjects with COPD and to longitudinal assessment of disease progression and outcome. This CORE is ideally positioned to meet these goals because it combines the strengths of collaborators with a past history of productivity in subject recruitment, and state of the art clinical, physiologic and quantitative radiographic characterization. It will ensure access to the well-characterized cohorts of the 3700 subjects of the Pittsburgh Lung Screening Study (PLuSS) and Emphysema COPD Research Center (ECRC) and its strong track record of contribution to 7 NHLBI funded clinical research contracts. In addition it will leverage off of access to the infrastructures of the NHLBI sponsored LTRC and the University of Pittsburgh Tissue Resource as well as a very active lung transplantation program to ensure access to high quality lung tissue. The third aim of this CORE extends the collaboration of the Radiology Research Group at the University of Pittsburgh and the Whole body Imaging Core of the (CAPTURE Centre to create a force with an international reputation in quantitative imaging who are each long term collaborators with Dr. Sciurba. We propose an iterative interaction between the clinical researchers on this project and the powerful imaging team. The preliminary data presented in project 1 and expanded upon in the clinical core reveal the existing structure and the strength of the existing collaboration and confirms the strong potential of this approach in meeting our goals of creating a new classification system for COPD in project 1, and offering innovative strategy for patient selection and outcome assessment in the context of disease modifying interventions such as in our project 4.