Clinical

临床

• 批准号: 7394643
• 负责人: FRANK SCIURBA
• 金额: $ 37.67万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-12 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394643
• 关键词: Arts; Chronic Obstructive Airway Disease; Classification; Clinical; Clinical Research; Collaborations; Complex; Data; Data Collection; Data Quality; Disease; Disease Progression; Ensure; Funding; Goals; Image; International; Intervention; Lung; Lung Transplantation; Outcome; Outcome Assessment; Patient Selection; Patients; Physiological; Population; Positioning Attribute; Productivity; Protocols documentation; Pulmonary Emphysema; Radiology Specialty; Recording of previous events; Recruitment Activity; Research; Research Contracts; Research Infrastructure; Research Personnel; Screening procedure; Structure; Structure of parenchyma of lung; System; Tissues; Universities; X-Ray Computed Tomography; cohort; innovation; programs; tissue resource; whole body imaging

The primary objective of the Clinical Core (CC) is to provide patient access and quality data collection including quantitative radiologic analysis to support the SCCOR in COPD at the University of Pittsburgh. To achieve these objectives, the research proposed will accomplish the following specific aims: A1. To access our diverse well characterized patient populations to efficiently recruit subjects for Projects 1 and 4 and maintain accessibility to tissue for Project 2. A2. To successfully assist in the execution of complex protocols, data collection and transfer of data to the ITBC core. A3. To apply quantitative computed tomography to the phenotypic characterization of subjects with COPD and to longitudinal assessment of disease progression and outcome. This CORE is ideally positioned to meet these goals because it combines the strengths of collaborators with a past history of productivity in subject recruitment, and state of the art clinical, physiologic and quantitative radiographic characterization. It will ensure access to the well-characterized cohorts of the 3700 subjects of the Pittsburgh Lung Screening Study (PLuSS) and Emphysema COPD Research Center (ECRC) and its strong track record of contribution to 7 NHLBI funded clinical research contracts. In addition it will leverage off of access to the infrastructures of the NHLBI sponsored LTRC and the University of Pittsburgh Tissue Resource as well as a very active lung transplantation program to ensure access to high quality lung tissue. The third aim of this CORE extends the collaboration of the Radiology Research Group at the University of Pittsburgh and the Whole body Imaging Core of the (CAPTURE Centre to create a force with an international reputation in quantitative imaging who are each long term collaborators with Dr. Sciurba. We propose an iterative interaction between the clinical researchers on this project and the powerful imaging team. The preliminary data presented in project 1 and expanded upon in the clinical core reveal the existing structure and the strength of the existing collaboration and confirms the strong potential of this approach in meeting our goals of creating a new classification system for COPD in project 1, and offering innovative strategy for patient selection and outcome assessment in the context of disease modifying interventions such as in our project 4.

临床核心（CC）的主要目标是提供患者访问和质量数据收集 包括定量放射学分析，以支持匹兹堡大学COPD的SCCOR。到 为了实现这些目标，拟议的研究将实现以下具体目标： A1.访问我们多样化的特征良好的患者人群，以有效招募项目受试者 1和4，并保持项目2的组织可及性。 A2.为了成功地协助执行复杂的协议，数据收集和数据传输， ITBC核心 A3.将定量计算机断层扫描应用于受试者的表型表征， COPD和疾病进展和结局的纵向评估。 该CORE是实现这些目标的理想定位，因为它结合了合作者的优势， 受试者招募的生产力历史，以及临床、生理和定量的最新技术水平 X射线照相表征。它将确保获得3700例受试者的特征明确的队列， 匹兹堡肺筛查研究（PLuSS）和肺气肿COPD研究中心（ECRC）及其 为7个NHLBI资助的临床研究合同做出贡献的良好记录。此外，它还将利用 获得NHLBI赞助的LTRC和匹兹堡大学组织的基础设施 资源以及非常活跃的肺移植计划，以确保获得高质量的肺组织。 该CORE的第三个目标是扩展了与纽约大学放射学研究小组的合作， 匹兹堡和全身成像的核心（CAPTURE中心，以创造一个具有国际性的力量 他们都是Sciurba博士的长期合作者。我们提出了一个 该项目的临床研究人员与强大的成像团队之间的迭代互动。的 项目1中提供的初步数据和临床核心中的扩展数据揭示了现有的结构 以及现有合作的优势，并证实了这种方法在满足 我们的目标是在项目1中为COPD创建一个新的分类系统，并提供创新策略， 在疾病修饰干预的背景下，患者选择和结果评估，例如在我们的 项目4.