IGF::OT::IGF LTRC CLINICAL CENTER - TASK ORDER 001; SUBJECT CHARACTERIZATION AND TISSUE PROCUREMENT

国家心肺血液研究所（NHLBI）肺组织研究联盟（LTRC）最初成立的主要目的是收集肺组织和血液样本，次要目的是收集慢性阻塞性肺疾病（COPD）、特发性肺纤维化（IPF）、慢性阻塞性肺疾病（COPD）和慢性阻塞性肺疾病（COPD）参与者的临床数据、有限暴露数据、生理学研究和放射学研究。其他相关的特发性间质性肺炎（IIP）和与结缔组织疾病相关的间质性肺炎，接受医学指示的肺切除术。LTRC III的主要重点将转向收集需要肺切除术的对照组患者的肺组织和临床数据。这些对照参与者主要来自疑似间质性肺疾病（ILD）的个体，他们在病理检查后显示没有这种疾病。对照参与者也可能来自疑似肺癌但肺功能正常的个体。对于这两种类型，非肿瘤组织将从结节或肿块远处收集。所有组织和血液标本以及临床数据将被储存起来，以供未来已批准研究计划并正在调查上述肺部疾病发病机制的研究者使用。本研究的最终目标是，从LTRC中获得的信息将为研究中的所有疾病类别带来新的介入治疗方法。

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was originally established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from participants with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic interstitial pneumonias (IIP) and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection. LTRC III’s primary focus will shift to the collection of lung tissue and clinical data from control participants who require lung resection. These control participants will primarily come from individuals with suspected interstitial lung disease (ILD) who are shown after pathological examination not to have this disease. Control participants may also come from individuals with suspected lung cancer but with normal lung function. For either category, non-neoplastic tissue will be collected remotely from a nodule or mass. All tissue and blood specimens and clinical data will be banked and stored for distribution to future investigators who have approved study proposals and are investigating the pathogenesis of the aforementioned lung diseases. It is the ultimate goal of this study that information derived from the LTRC will lead to novel interventional treatments for all disease categories under study.