IGF::OT::IGF LTRC CLINICAL CENTER - TASK ORDER 001; SUBJECT CHARACTERIZATION AND TISSUE PROCUREMENT

IGF::OT::IGF LTRC 临床中心 - 任务单 001；

• 批准号: 9304632
• 负责人: FRANK SCIURBA
• 金额: $ 22.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9304632
• 关键词: Appearance; Blood specimen; Categories; Chronic Obstructive Airway Disease; Clinical; Clinical Data; Collection; Connective Tissue Diseases; Data; Disease; Excision; Future; Goals; Hamman-Rich syndrome; Image; Individual; Interstitial Lung Diseases; Interstitial Pneumonia; Lead; Lung; Lung diseases; Malignant neoplasm of lung; National Heart, Lung, and Blood Institute; Nodule; Operative Surgical Procedures; Participant; Pathogenesis; Physiological; Research; Research Personnel; Respiratory physiology; Structure of parenchyma of lung; Tissue Procurements; Tissue Sample; Tissues; lung metastatic; meetings; novel

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was originally established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from participants with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic interstitial pneumonias (IIP) and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection. LTRC III’s primary focus will shift to the collection of lung tissue and clinical data from control participants who require lung resection. These control participants will primarily come from individuals with suspected interstitial lung disease (ILD) who are shown after pathological examination not to have this disease. Control participants may also come from individuals with suspected lung cancer but with normal lung function. For either category, non-neoplastic tissue will be collected remotely from a nodule or mass. All tissue and blood specimens and clinical data will be banked and stored for distribution to future investigators who have approved study proposals and are investigating the pathogenesis of the aforementioned lung diseases. It is the ultimate goal of this study that information derived from the LTRC will lead to novel interventional treatments for all disease categories under study.

美国国家心肺血液研究所（NHLBI）肺组织研究联盟（LTRC）最初成立的主要目的是收集肺组织和血液样本，次要目的是收集慢性阻塞性肺疾病（COPD）、特发性肺纤维化（IPF）、其他相关的特发性间质性肺炎（IIP）和与结缔组织疾病相关的间质性肺炎，接受医学指征肺切除术。LTRC III的主要重点将转移到需要肺切除术的对照参与者的肺组织和临床数据的收集。这些对照受试者将主要来自疑似间质性肺病（ILD）的个体，这些个体在病理检查后显示没有这种疾病。对照参与者也可能来自疑似肺癌但肺功能正常的个体。对于任一类别，将从结节或肿块远程采集非肿瘤组织。所有组织和血液样本以及临床数据将被储存并分发给已批准研究方案并正在研究上述肺部疾病发病机制的未来研究者。本研究的最终目标是，从LTRC获得的信息将为研究中的所有疾病类别提供新的介入治疗。