Online pharmaceutical granule moisture distribution measurement and feedback control of fluidised bed dryers

流化床干燥机药品颗粒水分分布在线测量与反馈控制

• 批准号: EP/G005702/1
• 负责人: Wuqiang Yang
• 金额: $ 13.82万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG005702%2F1
• 关键词: Online; pharmaceutical; granule; moisture; distribution

Fluidised bed dryers in the pharmaceutical industry are currently operated by trial-and-error because of the lack of means for online measurement of granule moisture. This proposed project is to follow a current EPSRC project Product quality control of fluidised bed dryers with tomographic imaging and online process modelling (GR/S14726/01). While we have made good progress on fundamental understanding of the complicated fluidisation processes and online measurement of granule moisture and also our research results have attracted considerable interest from industry, it is necessary to bridge the gap between the current funding and future commercial funding. The aim of this proposed Follow-on project is to meet this need by scaling up from a lab scale dryer to semi-industrial scale dryers, re-engineering electrical capacitance tomography (ECT) sensors and demonstrating the principle of online measurement of granule moisture and feedback control of semi-industrial scale fluidised bed dryers in an industrial lab environment. The success of this project will advance the technology to a stronger position to attract commercial interest and further commercial seed funding, helping the UK fluidised bed dryer manufacturing industry and the UK pharmaceutical industry to increase their competitiveness in the world. As a key collaborator, GEA Process Engineering (NPS) Ltd will provide strong support to the project by providing semi-industrial scale facilities, re-engineering sensors and giving technical and market advice. Sherwood Scientific Ltd, Sensatech Research Ltd and DuPont will also support the project as industrial partners and have expressed their interest in commercialisation. The University of Manchester Intellectual Property (UMIP) Ltd has filed a UK Patent (GB0717080.6) to protect the outputs of the current project, has managed the commercial aspect of the current EPSRC project, and has included this proposed project in their active project portfolio. It is anticipated that by demonstrating this patented technology on semi-industrial scale fluidised bed dryers, a number of other applications would open up in other industries, e.g. the food, marine, power and process industries.

由于缺乏在线测量颗粒水分的手段，制药工业中的流化床干燥机目前通过试错操作。本拟议项目将遵循当前EPSRC项目，采用断层成像和在线过程建模对流化床干燥机进行产品质量控制（GR/S14726/01）。虽然我们已经取得了良好的进展，基本了解复杂的流化过程和在线测量颗粒水分，我们的研究成果也吸引了相当大的兴趣，从工业，有必要弥合目前的资金和未来的商业资金之间的差距。该后续项目的目的是通过将实验室规模的干燥机扩大到半工业规模的干燥机来满足这一需求，重新设计电容层析成像（ECT）传感器，并在工业实验室环境中演示颗粒水分在线测量和半工业规模流化床干燥机反馈控制的原理。该项目的成功将使该技术处于更有利的地位，以吸引商业兴趣和进一步的商业种子资金，帮助英国流化床干燥机制造业和英国制药业提高其在世界上的竞争力。作为主要合作伙伴，GEA Process Engineering（GEA）Ltd将通过提供半工业规模的设施、重新设计传感器以及提供技术和市场建议，为该项目提供强有力的支持。舍伍德科学有限公司、Sensatech研究有限公司和杜邦公司也将作为工业合作伙伴支持该项目，并表示有兴趣将其商业化。曼彻斯特大学知识产权（UMIP）有限公司已申请英国专利（GB0717080.6），以保护当前项目的产出，管理当前EPSRC项目的商业方面，并将该拟议项目纳入其积极的项目组合。预计通过在半工业规模的流化床干燥机上展示这项专利技术，将在其他行业（例如食品，海洋，电力和加工行业）中开辟许多其他应用。

项目成果

Fringe effect of electrical capacitance and resistance tomography sensors

• DOI: 10.1088/0957-0233/24/7/074002
• 发表时间: 2013-07-01
• 期刊: MEASUREMENT SCIENCE AND TECHNOLOGY
• 影响因子: 2.4
• 作者: Sun, Jiangtao;Yang, Wuqiang
• 通讯作者: Yang, Wuqiang

Measurement of particle concentration in a Wurster fluidized bed by electrical capacitance tomography sensors

• DOI: 10.1002/aic.14595
• 发表时间: 2014-12
• 期刊: Aiche Journal
• 影响因子: 3.7
• 作者: Ruihuan Ge;Jiamin Ye;Haigang Wang;Wuqiang Yang

Evaluation of fringe effect of electrical resistance tomography sensor

• DOI: 10.1016/j.measurement.2014.03.039
• 发表时间: 2014-07-01
• 期刊: MEASUREMENT
• 影响因子: 5.6
• 作者: Sun, Jiangtao;Yang, Wuqiang
• 通讯作者: Yang, Wuqiang

3D imaging with single-plane electrical capacitance tomography sensor

• DOI: 10.1049/el.2014.3667
• 发表时间: 2015-02
• 期刊: Electronics Letters
• 影响因子: 1.1
• 作者: Jiangtao Sun;Z. Ren;Wuqiang Yang

Investigation of flow hydrodynamics and regime transition in a gas-solids fluidized bed with different riser diameters

• DOI: 10.1016/j.ces.2014.05.006
• 发表时间: 2014-09
• 期刊: Chemical Engineering Science
• 影响因子: 4.7
• 作者: G. Qiu;Jiamin Ye;Haigang Wang;Wuqiang Yang