Online measurement of moisture distribution in pharmaceutical fluidised beds for drying, granulation and coating

在线测量用于干燥、制粒和包衣的制药流化床中的水分分布

• 批准号: EP/H502327/1
• 负责人: Wuqiang Yang
• 金额: $ 12.8万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH502327%2F1
• 关键词: Online; measurement; moisture; distribution; pharmaceutical

Gas-solids fluidised beds are commonly used in the pharmaceutical industry for drying, granulation and coating. Because of the lack of means for online measurement of granule moisture, the fluidised beds are currently operated by trial-and-error, resulting in low operation efficiency (i.e. longer operation time and more energy consumed), and more importantly the product quality cannot be guaranteed. During two recent EPSRC projects (GR/T29383/01, EP/G005702/1), we have made significant progress on fundamental understanding of the complicated gas-solids fluidisation processes and online measurement of granule moisture in fluidised bed dryers, which have been demonstrated on lab-scale fluidised bed dryers both at the University of Manchester (UoM) and in GEA Pharma Systems Ltd and also published in prestigious journals, e.g. AIChE J. In the past 12 months, our EPSRC Follow-on Fund project has allowed the technology to be scaled up from lab dryers to semi-industrial scale dryers and demonstration of the principle of online measurement of granule moisture in semi-industrial scale dryers in an industrial lab environment. This work, in collaboration with GEA and other industrial partners, has generated considerable interest from the pharmaceutical industry, notably AstraZeneca, who has expressed a wish to collaborate on the next stage of development with a view of becoming the first adopter of the technology.

气固流态化床通常用于制药工业的干燥、造粒和包衣。由于缺乏在线测量颗粒水分的手段，目前的流态化床是反复操作的，导致运行效率低(即运行时间长、能耗大)，更重要的是产品质量得不到保证。在最近的两个EPSRC项目(GR/T29383/01，EP/G005702/1)中，我们在对复杂的气固流态化过程的基本了解和流态化床干燥器中颗粒水分的在线测量方面取得了重大进展，这些已经在曼彻斯特大学(UOM)和Gea Pharma Systems Ltd的实验室规模的流态化床干燥器上进行了演示，并发表在著名期刊上，例如，在过去的12个月里，我们的EPSRC后续基金项目使该技术从实验室干燥机扩大到半工业规模的干燥机，并在工业实验室环境中演示了半工业规模干燥机中颗粒水分的在线测量原理。这项与GEA和其他工业合作伙伴合作的工作引起了制药行业的极大兴趣，特别是阿斯利康，他们表示希望在下一阶段的开发中进行合作，以期成为该技术的第一个采用者。

项目成果

Real-time 3D image reconstruction for ECT

ECT 的实时 3D 图像重建

• 作者: Lei Ye (Author)

Measurement of particle concentration in a Wurster fluidized bed by electrical capacitance tomography sensors

• DOI: 10.1002/aic.14595
• 发表时间: 2014-12
• 期刊: Aiche Journal
• 影响因子: 3.7
• 作者: Ruihuan Ge;Jiamin Ye;Haigang Wang;Wuqiang Yang

Monitoring fluidised bed coating process with electrical capacitance tomography

使用电容断层扫描监测流化床包衣过程

• 作者: Haigang Wang (Author)

Investigation of flow hydrodynamics and regime transition in a gas-solids fluidized bed with different riser diameters

• DOI: 10.1016/j.ces.2014.05.006
• 发表时间: 2014-09
• 期刊: Chemical Engineering Science
• 影响因子: 4.7
• 作者: G. Qiu;Jiamin Ye;Haigang Wang;Wuqiang Yang

Imaging pharmaceutical multi-processes in fluidized bed by electrical capacitance tomography

通过电容层析成像对流化床中的制药多过程进行成像

• 发表时间: 2010
• 作者: Haigang Wang