University of Washington Emission Tomography Simulation Resource

华盛顿大学发射断层扫描模拟资源

• 批准号: 7484116
• 负责人: THOMAS K LEWELLEN
• 金额: $ 23.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7484116
• 关键词: Acceleration; Address; Adopted; Binding; Clinical; Clinical Research Protocols; Code; Collimator; Communities; Complement; Computer Systems; Computer software; Data; Data Set; Descriptor; Detection; Development; Device or Instrument Development; Disease; Documentation; Emission-Computed Tomography; Funding; General Population; Goals; Hand; Housing; Image; Language; Lead; Licensing; Medical Imaging; Modeling; Modification; Monitor; Noise; Output; Penetration; Photons; Play; Pliability; Positron-Emission Tomography; Problem Solving; Property; Public Domains; Radiation; Research; Research Personnel; Research Project Grants; Resources; Role; Scanning; Simulate; Software Engineering; Solutions; Source; Source Code; Speed; Statistical Models; Structure; System; Techniques; Text; Time; Tomography, Computed, Scanners; Translating; Universities; Variant; Washington; Work; base; cost; data modeling; design; desire; detector; improved; innovation; models and simulation; open source; programs; prototype; response; simulation; single photon emission computed tomography; tomography; tool

DESCRIPTION (provided by applicant): Simulation plays a critical role in the development of new emission tomography scanners and innovative applications of such scanners. These applications include the detection and monitoring response to therapy of a wide variety of diseases. For the past 19 years, our group has been developing a Monte Carlo simulation system specifically designed to simulate positron emission tomography (PET) and single emission tomography (SPECT) scanners. The work has been in support of our funded research projects in instrument development and optimization. From the first, we designed the code to be easily implemented on most computer systems. Recognizing that others might want to use the code as well, we adapted formal software engineering approaches in the design and coding of the software. The code has proven to be very useful to a wide user community (over 250 current users that we know about) and has been a key in many research projects. Our goal is now to extend parts of the code to make it more useful for researchers working on projects that have different needs than our own work, and to adopt a more formal open source release so that the work of others to extend the code can be incorporated in a controlled and well documented fashion to the existing code base. The proposed additions to the code include more acceleration techniques, dynamic scans, improved collimator simulations, and more efficient user interfaces and documentation. To address the increasing need of researchers for multiple realizations (e.g. thousands) of data sets, we also propose to recode our internal analytic simulation code (ASIM) and provide both ASIM and SimSET with a common interface and object descriptor meta language to improve consistency, error checking, and ease of use. The codes will be re-designed so that SimSET can be used to determine the parametric models ASIM requires, making the two tools a synergistic solution to many compute-bound problems faced by us and other users of SimSET. The codes fill an important role in emission tomograph research. While other Monte Carlo systems such as GATE can provide more detailed simulations of tomographs, they do so at a significant cost in speed. SimSET and ASIM allow the user to more finely tune the level of detail desired and then to exploit the many acceleration techniques in SimSET and ASIM to obtain an efficient simulation tool for the medical imaging task at hand. Establishing both SimSET and ASIM as formal open source projects will also expedite the enhancement of these two tools for a wide variety of research applications.

描述（由申请人提供）：模拟在新的排放层析成像扫描仪和此类扫描仪的创新应用中起着至关重要的作用。这些应用包括对多种疾病治疗的检测和监测反应。在过去的19年中，我们的小组一直在开发一个蒙特卡洛模拟系统，专门设计用于模拟正电子发射断层扫描（PET）和单发射断层扫描仪（SPECT）扫描仪。这项工作一直支持我们在仪器开发和优化方面的资助研究项目。从首先开始，我们设计了代码，可以轻松在大多数计算机系统上实现。认识到其他人也可能想使用代码，我们在软件的设计和编码中调整了正式的软件工程方法。事实证明，该代码对广泛的用户社区非常有用（我们知道的250多个现有用户），并且是许多研究项目的关键。现在，我们的目标是扩展代码的一部分，以使其对于从事与我们自己的工作不同的项目的研究人员更有用，并采用更正式的开源释放，以便其他人可以以受控且文档的方式将其扩展到现有的代码库中。该代码的提议添加包括更多的加速技术，动态扫描，改进的准直仪模拟以及更有效的用户界面和文档。为了满足研究人员对数据集多种实现（例如数千个）的需求，我们还建议重新编码我们的内部分析模拟代码（ASIM），并为ASIM和SIMSET提供通用的接口和对象描述符元语言，以提高一致性，错误检查和使用。这些代码将经过重新设计，以便可以使用SimSet来确定ASIM所需的参数模型，从而使这两个工具成为我们和SimSet的其他许多计算结合问题的协同解决方案。这些代码在排放断层扫描研究中的重要作用。尽管其他蒙特卡洛系统（例如Gate）可以提供更详细的层状模拟，但它们的速度很高。 SimSet和ASIM允许用户更细微地调整所需的细节级别，然后利用SimSet和ASIM中的许多加速技术，以获取用于手头医学成像任务的有效仿真工具。建立SimSet和ASIM作为正式的开源项目也将加快增强这两种工具的各种研究应用程序。