UWMC POSITRON EMISSION IMAGING ANIMAL FACILITY

UWMC 正电子发射成像动物设施

基本信息

批准号：
6847446
负责人：
THOMAS K LEWELLEN
金额：
$ 30.4万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-03-01 至 2007-02-28
项目状态：
已结题

项目摘要

DESCRIPTION: (Applicant's Description) The proposed resource will provide positron imaging of small animals for NCI funded investigators at the University of Washington. Two small animal machines will be constructed and supported for imaging studies. These systems will implement detector and electronics technology that has been under development in our laboratory for the past six years. The recent availability of new, multi-cathode photomultiplier tubes PMTs) and a reliable source of Lutetium Oxyorthosilicate (LSO) crystals has now made it possible to build these systems for general use. The first system is optimized for imaging mice and small rats. It will have a 12 cm ring diameter, providing an 8 cm transverse field-of-view (FOV). This system will utilize 0.8x0.8x6 mm LSO crystals to provide a limiting resolution of approximately 1 mm. The system will ultimately support three rings of modules spanning 6.7 cm axially. The system will first be built with a single ring of modules and made available for use by the end of the first year of finding. During the second year, the additional two rings will be added. A unique feature of this system is that the second and third rings are movable in the axial direction. In this way, the system can be operated with all three module rings adjacent or disjoint (e.g., two adjacent over the head and one over the heart so that an input function can be measured by imaging the ventricle). The second system will have a 20 cm ring diameter, providing a 15 cm FOV and is designed to image large rats, rabbits, and small primate heads. This is a more complex system with 2x2x20 mm LSO crystals that uses depth-of-interaction information to preserve radial resolution. The complete system will consist of 24 rings of crystals (8 rings in each of three module rings). A DOI system with a single ring of modules will be complete by the beginning of year 3. The remaining two rings will be constructed and installed during years 3 to 5; The last ring will be moveable in the axial direction. The resource personnel will provide support for imaging (technologist time, calibrations, image reconstruction, and assistance with image analysis). Animal support and radiopharmaceuticals will be provided by existing cost centers within the University of Washington Department of Radiology.

描述：（申请人的描述）拟议的资源将提供 NCI资助的研究人员的小动物的正电子成像华盛顿大学。将建造两台小型动物机器支持成像研究。这些系统将实施检测器，并我们实验室正在开发的电子技术过去六年。最新的新型多音量可用性光电塑料管PMT）和可靠的含氧硅酸盐来源（LSO）晶体现在使得为一般建造这些系统成为可能使用。第一个系统已针对小鼠和小鼠的成像进行了优化。它将有一个 12厘米环直径，提供8厘米的横向视野（FOV）。这系统将利用0.8x0.8x6 mm LSO晶体提供限制分辨率约1毫米。该系统最终将支持三个环轴向横跨6.7 cm的模块。该系统将首先使用一个模块环，可在第一年结束前使用发现。在第二年，将增加两个环。一个该系统的独特功能是第二个和第三个环是可移动的沿轴向方向。这样，系统可以使用这三个操作模块环相邻或不相交（例如，头部邻近两个，一个在心脏上，可以通过成像来测量输入函数心室）。第二个系统将具有20厘米的环直径，提供15厘米的FOV和旨在成像大鼠，兔子和小灵长类动物头。这是一个使用2x2x20 mm LSO晶体的更复杂的系统，使用深度相互作用信息以保留径向分辨率。完整的系统将包括 24个晶体环（三个模块环中的每个环）。 DOI系统在第3年初，将使用单个模块圈完成。剩余的两个环将在3至5年内建造和安装；这最后一个环将在轴向方向上移动。资源人员将为成像提供支持（技术人员时间，校准，图像重建和图像分析的帮助）。动物支持和放射性药物将由现有成本提供华盛顿大学放射学系的中心。