Ultrasound induced vessel thrombosis for treatment of Gastric varices

超声诱导血管血栓形成治疗胃静脉曲张

• 批准号: 7465505
• 负责人: JOO HA HWANG
• 金额: $ 12.56万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7465505
• 关键词: Ablation; Acoustics; Animal Model; Animals; Award; Biological; Blood Vessels; Blood capillaries; Caliber; Cell Death; Cell membrane; Clinical; Coagulation Process; Complex; Contrast Media; Development; Development Plans; Diagnostic; Disruption; Emerging Technologies; Endothelial Cells; Engineering; Esophageal and Gastric Varices; Focused Ultrasound Therapy; Gases; Gastric Varices; Gastroenterology; Gene Delivery; Goals; Heating; Hemorrhage; Hemorrhoids; Hemostatic function; Intravascular Thrombus Formation; Investigation; Lead; Mechanics; Mediating; Mentors; Methods; Microbubbles; Pharmaceutical Preparations; Phase; Physiologic pulse; Platelet Activation; Process; Pulse taking; Purpose; Research; Research Personnel; Research Proposals; Role; Rupture; Sclerotherapy; Structure; System; Testing; Therapeutic; Thrombosis; Time; Tissues; Transducers; Translating; Uca; Ultrasonic Therapy; Ultrasonic Transducer; Ultrasonography; Varicosity; Vascular Endothelium; Venous; Violence; artery occlusion; base; capillary; career; cell injury; design and construction; experience; gastrointestinal; heart visualization; improved; in vivo; interest; multidisciplinary; novel; pressure; prototype; skills; thrombolysis; tumor; vapor

DESCRIPTION (provided by applicant): This purpose of this Research Career Award proposal is to outline a multidisciplinary line of investigation in the field of high-intensity therapeutic ultrasound with potential applications to gastrointestinal bleeding that will be used as a vehicle to gain additional scientific and engineering research experience in a mentored setting. The overall goal of this proposal is to develop a skill set that will enable me to become a highly competent and competitive independent scientific investigator applying engineering and scientific principles to solve clinical problems in the field of gastroenterology. In addition, a supplemental career development plan that includes additional coursework, career development seminars, and the formation of a scientific/career development supervisory committee is proposed. The overall purpose of the proposed research is to investigate the role of ultrasound-targeted vessel occlusion for the treatment of gastric varices. Although ultrasound is most commonly used for diagnostic purposes clinically, it is also capable of delivering energy to tissue for therapeutic purposes. At higher intensities, ultrasound has known bioeffects such as tissue heating and mechanical disruption due to cavitation. Initial studies have investigated the bioeffects that result from the exposure of blood vessels to HIFU, particularly in the setting of circulating ultrasound contrast agent (UCA). It has been demonstrated that pulsed HIFU in combination with microbubble contrast agent can lead to endothelial damage resulting in platelet activation and intravascular thrombus formation. Furthermore, it has been demonstrated that this method can be used to target vessel occlusion. This project proposes to translate basic ultrasound bioeffects studies into a clinically useful approach for treating gastric varices. The proposed studies will examine the ability of ultrasound-mediated vascular occlusion in achieving hemostasis in actively bleeding blood vessels. A prototype endoscopic transducer will be constructed to test the feasibility of ultrasound-mediated vessel occlusion in treating gastric varices in a large animal model. The overall hypothesis of this project is that ultrasound-mediated vascular occlusion can achieve hemostasis in actively bleeding blood vessels and occlude and obliterate a targeted segment of a blood vessel. This method can be translated to a clinically useful approach for the treatment of gastric varices with the development of an endoscopic-based ultrasound transducer

描述（由申请人提供）： 该研究职业奖提案的这一目的是概述高强度治疗超声领域的多学科调查线，并可能在胃肠道出血中应用，该领域将用作获得额外的科学和工程研究经验的工具。该提案的总体目标是开发一种技能，使我能够成为应用工程学和科学原理来解决胃肠病学领域的临床问题的高度竞争和竞争性的独立科学研究者。此外，提出了一项补充职业发展计划，包括其他课程，职业发展研讨会以及科学/职业发展监督委员会的成立。 拟议研究的总体目的是研究超声靶向血管闭塞在治疗胃静脉曲张方面的作用。尽管超声最常用于临床诊断目的，但它也能够以治疗目的将能量输送到组织。在较高的强度下，超声具有已知的生物效应，例如组织加热和由于气腔引起的机械破坏。最初的研究研究了血管暴露于HIFU所致的生物效应，特别是在循环超声对比剂（UCA）的情况下。已经证明，脉冲HIFU与微泡对比剂结合使用会导致内皮损伤，从而导致血小板激活和血管内血栓形成。此外，已经证明该方法可用于靶向血管阻塞。该项目建议将基本的超声生物效应研究转化为一种治疗胃静脉曲张的临床有用方法。拟议的研究将检查超声介导的血管阻塞在积极流血血管中止血的能力。将构建原型内窥镜换能器，以测试超声介导的血管阻塞在大型动物模型中处理胃静脉曲张中的可行性。该项目的总体假设是，超声介导的血管闭塞可以在积极出血血管中止血，并闭塞并消除血管的靶向段。该方法可以转化为一种临床上有用的方法，用于通过基于内窥镜的超声传感器的发展来治疗胃静脉曲张