Project 3: Molecular Risk Stratification of Gastric Precancerous Lesions

项目3:胃癌前病变分子风险分层

基本信息

  • 批准号:
    10715764
  • 负责人:
  • 金额:
    $ 38.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-20 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT – PROJECT 3 Project 3 proposes a concerted effort to decrease the 10-15% rate of Helicobacter pylori (Hp) recrudescence that is currently experienced by patients. Previous work by the investigators in this Program Project Grant has shown that a small number of Hp colonies persist deep within the gastric glands after eradication therapy. These colonies may not be detected using conventional clinical tests, as the colonies reside in recrudescence niches that are consequently resistant to antibiotic treatment. Highly sensitive molecular technology can reveal the presence of Hp in conventionally ‘negative’ gastric histology samples. The central hypothesis of Project 3 is that use of highly sensitive, sequencing-based technology to identify persistent Hp organisms and guide eradication may both prevent Hp recrudescence and arrest neoplastic progression. The specific aims of Project 3 are: (1) Leverage gene expression profiles of gastric epithelial cells as a predictor of gastric intestinal metaplasia (GIM) progression in Hp negative individuals. (2) Develop molecular risk-stratification strategies in Hp histology negative subjects. In Aim 1, 300 Hp negative subjects will undergo RNA sequencing, and concordance with the ‘high-risk’ patterns will be assessed through a gene expression vector. We will then translate the ‘high-risk’ expression signature into a clinically useful multiplex IHC test. In Aim 2, samples from patients with GIM who are histology negative for Hp on biopsies will be sequenced for molecular detection of Hp. A subset of patients will participate in a randomized, placebo-controlled trial evaluating the effect of antibiotic therapy on molecular Hp titers. This trial will demonstrate whether a sequencing-based eradication strategy can reduce Hp burden to molecularly undetectable levels in human subjects.
摘要-项目3

项目成果

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JOO HA HWANG其他文献

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{{ truncateString('JOO HA HWANG', 18)}}的其他基金

Precision Interception of Gastric Cancer Precursors Through Molecular and Cellular Risk Stratification
通过分子和细胞风险分层精准拦截胃癌前体
  • 批准号:
    10715761
  • 财政年份:
    2023
  • 资助金额:
    $ 38.95万
  • 项目类别:
Ultrasound-enhanced drug penetration for treatment of pancreatic cancer
超声增强药物渗透治疗胰腺癌
  • 批准号:
    10198853
  • 财政年份:
    2020
  • 资助金额:
    $ 38.95万
  • 项目类别:
Ultrasound enhanced penetration for treatment of pancreatic cancer
超声增强穿透治疗胰腺癌
  • 批准号:
    8184046
  • 财政年份:
    2011
  • 资助金额:
    $ 38.95万
  • 项目类别:
Ultrasound enhanced penetration for treatment of pancreatic cancer
超声增强穿透治疗胰腺癌
  • 批准号:
    8531683
  • 财政年份:
    2011
  • 资助金额:
    $ 38.95万
  • 项目类别:
Ultrasound enhanced penetration for treatment of pancreatic cancer
超声增强穿透治疗胰腺癌
  • 批准号:
    8332761
  • 财政年份:
    2011
  • 资助金额:
    $ 38.95万
  • 项目类别:
High intensity focused ultrasound enhanced drug delivery for local therapy of hep
高强度聚焦超声增强药物输送用于肝癌局部治疗
  • 批准号:
    7708093
  • 财政年份:
    2009
  • 资助金额:
    $ 38.95万
  • 项目类别:
High intensity focused ultrasound enhanced drug delivery for local therapy of hep
高强度聚焦超声增强药物输送用于肝癌局部治疗
  • 批准号:
    7873039
  • 财政年份:
    2009
  • 资助金额:
    $ 38.95万
  • 项目类别:
Ultrasound induced vessel thrombosis for treatment of Gastric varices
超声诱导血管血栓形成治疗胃静脉曲张
  • 批准号:
    7465505
  • 财政年份:
    2006
  • 资助金额:
    $ 38.95万
  • 项目类别:
Ultrasound induced vessel thrombosis for treatment of Gastric varices
超声诱导血管血栓形成治疗胃静脉曲张
  • 批准号:
    7216194
  • 财政年份:
    2006
  • 资助金额:
    $ 38.95万
  • 项目类别:
Ultrasound induced vessel thrombosis for treatment of Gastric varices
超声诱导血管血栓形成治疗胃静脉曲张
  • 批准号:
    7870510
  • 财政年份:
    2006
  • 资助金额:
    $ 38.95万
  • 项目类别:

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