Ultrasound induced vessel thrombosis for treatment of Gastric varices

超声诱导血管血栓形成治疗胃静脉曲张

• 批准号: 7870510
• 负责人: JOO HA HWANG
• 金额: $ 12.56万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7870510
• 关键词: Ablation; Acoustics; Animal Model; Animals; Award; Biological; Blood Vessels; Blood capillaries; Caliber; Cell Death; Cell membrane; Clinical; Coagulation Process; Complex; Contrast Media; Development; Development Plans; Diagnostic; Emerging Technologies; Endothelial Cells; Engineering; Esophageal and Gastric Varices; Focused Ultrasound Therapy; Gases; Gastric Varices; Gastroenterology; Gene Delivery; Goals; Heating; Hemorrhage; Hemorrhoids; Hemostatic function; Intravascular Thrombus Formation; Investigation; Lead; Mechanics; Mediating; Mentors; Methods; Microbubbles; Pharmaceutical Preparations; Phase; Physiologic pulse; Platelet Activation; Process; Research; Research Personnel; Research Proposals; Role; Rupture; Sclerotherapy; Structure; System; Testing; Therapeutic; Thrombosis; Time; Tissues; Transducers; Translating; Uca; Ultrasonic Therapy; Ultrasonic Transducer; Ultrasonography; Varicosity; Vascular Endothelium; Venous; Violence; artery occlusion; base; capillary; career; career development; cell injury; design and construction; experience; gastrointestinal; heart visualization; improved; in vivo; interest; multidisciplinary; novel; pressure; prototype; skills; thrombolysis; tumor; vapor

DESCRIPTION (provided by applicant): This purpose of this Research Career Award proposal is to outline a multidisciplinary line of investigation in the field of high-intensity therapeutic ultrasound with potential applications to gastrointestinal bleeding that will be used as a vehicle to gain additional scientific and engineering research experience in a mentored setting. The overall goal of this proposal is to develop a skill set that will enable me to become a highly competent and competitive independent scientific investigator applying engineering and scientific principles to solve clinical problems in the field of gastroenterology. In addition, a supplemental career development plan that includes additional coursework, career development seminars, and the formation of a scientific/career development supervisory committee is proposed. The overall purpose of the proposed research is to investigate the role of ultrasound-targeted vessel occlusion for the treatment of gastric varices. Although ultrasound is most commonly used for diagnostic purposes clinically, it is also capable of delivering energy to tissue for therapeutic purposes. At higher intensities, ultrasound has known bioeffects such as tissue heating and mechanical disruption due to cavitation. Initial studies have investigated the bioeffects that result from the exposure of blood vessels to HIFU, particularly in the setting of circulating ultrasound contrast agent (UCA). It has been demonstrated that pulsed HIFU in combination with microbubble contrast agent can lead to endothelial damage resulting in platelet activation and intravascular thrombus formation. Furthermore, it has been demonstrated that this method can be used to target vessel occlusion. This project proposes to translate basic ultrasound bioeffects studies into a clinically useful approach for treating gastric varices. The proposed studies will examine the ability of ultrasound-mediated vascular occlusion in achieving hemostasis in actively bleeding blood vessels. A prototype endoscopic transducer will be constructed to test the feasibility of ultrasound-mediated vessel occlusion in treating gastric varices in a large animal model. The overall hypothesis of this project is that ultrasound-mediated vascular occlusion can achieve hemostasis in actively bleeding blood vessels and occlude and obliterate a targeted segment of a blood vessel. This method can be translated to a clinically useful approach for the treatment of gastric varices with the development of an endoscopic-based ultrasound transducer

描述（由申请人提供）：

项目成果

Targeted long-term venous occlusion using pulsed high-intensity focused ultrasound combined with a pro-inflammatory agent.

使用脉冲高强度聚焦超声结合促炎剂进行有针对性的长期静脉闭塞。

• DOI: 10.1016/j.ultrasmedbio.2011.06.007
• 发表时间: 2011
• 期刊: Ultrasound in medicine & biology
• 影响因子: 2.9
• 作者: Zhou,Yufeng;Zia,Jasmine;Warren,Cinderella;Starr,FrankL;Brayman,AndrewA;Crum,LawrenceA;Hwang,JooHa
• 通讯作者: Hwang,JooHa