Sidekick proteins in HIV-associated nephropathy

HIV 相关肾病中的 Sidekick 蛋白

基本信息

  • 批准号:
    7692402
  • 负责人:
  • 金额:
    $ 0.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-07-01 至 2010-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): HIV-associated nephropathy (HIVAN) is a leading cause of renal failure in Blacks. The main pathologic feature of HIVAN is collapsing glomerulopathy, which is caused by the direct infection of podocytes by HIV-1. Infected podocytes show unique phenotypic changes including dedifferentiation, increased proliferation, and changes in the actin cytoskeleton. We have cloned a host gene named sidekick-1 (sdk-1), a transmembrane protein of the immunoglobulin superfamily, as being highly upregulated in HIV-1 transgenic podocytes, and we believe sdk-1 to have a key role in HIVAN pathogenesis. We have shown that sdk-1 is highly upregulated in glomeruli in both HIV-1 transgenic mice and in human kidney biopsies. Our data also show that sdk-1 and its ortholog sidekick-2 (sdk-2) function as homophilic adhesion molecules in cells such that each sidekick prefers to bind to its own kind, and we have begun to map the domains responsible. Moreover, sdk-1 and sdk-2 were shown by others to function as neuronal guidance molecules, targeting axons to specific synapses; this suggests that sdk-1 and sdk-2 may analogously have a critical role in determining and maintaining glomerular architecture normally and in disease. In this proposal: 1. We will determine: a) the critical domain(s) of sdk-1 and sdk-2 responsible for the specificity of sdk-1 and sdk-2's homophilic interactions; b) whether targeted disruption of this critical domain's function in HIV-1 podocytes in vitro and in vivo can prevent HIV-1 induced phenotypic changes. 2. We will identify phenotypic changes in podocytes induced by sdk-1 expression. We will determine: a) to what extent does targeted overexpression of sdk-1 in podocytes in transgenic mice recapitulate HIVAN pathophysiology; b) how overexpression of sdk-1 in podocytes effects their ability to interact with glomerular basement membrane components; c) if sdk-1 upregulation induced by HIV-1 infection changes podocye-podocyte adhesion in vitro? 3. We will characterize the interaction of sdk-1 with the actin cytoskeleton. We will identify:a) the potential intracellular sdk-1 interacting proteins including alpha actinin-4; b) the effects of sdk-1 expression on organization of actin filaments and microtubules in podocytes and on expression of other actin-associated molecules. 4. We will better characterize expression patterns of sdk-1 in normal kidney, HIVAN and other glomerular diseases and examine differences in sdk-1 and sdk-2 expression between HIVAN susceptible and HIVAN resistant mouse strains. These studies should elucidate the mechanisms by which sdk-1 contributes to podocyte dysfunction in HIVAN.
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Lewis Kaufman其他文献

Lewis Kaufman的其他文献

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{{ truncateString('Lewis Kaufman', 18)}}的其他基金

Podocyte-specific Rap1 agonism for treatment of glomerular disease
足细胞特异性 Rap1 激动剂治疗肾小球疾病
  • 批准号:
    10441968
  • 财政年份:
    2022
  • 资助金额:
    $ 0.1万
  • 项目类别:
Podocyte-specific Rap1 agonism for treatment of glomerular disease
足细胞特异性 Rap1 激动剂治疗肾小球疾病
  • 批准号:
    10588172
  • 财政年份:
    2022
  • 资助金额:
    $ 0.1万
  • 项目类别:
DACH1 transcriptomic regulation of glucocorticoid-responsive glomerular disease
DACH1 糖皮质激素反应性肾小球疾病的转录组调控
  • 批准号:
    10338127
  • 财政年份:
    2020
  • 资助金额:
    $ 0.1万
  • 项目类别:
DACH1 transcriptomic regulation of glucocorticoid-responsive glomerular disease
DACH1 糖皮质激素反应性肾小球疾病的转录组调控
  • 批准号:
    10551285
  • 财政年份:
    2020
  • 资助金额:
    $ 0.1万
  • 项目类别:
Sidekick-1 Upregulation in Podocytes Induces FSGS by Disrupting MAGI-1 Function
足细胞中 Sidekick-1 上调通过破坏 MAGI-1 功能诱导 FSGS
  • 批准号:
    8509679
  • 财政年份:
    2009
  • 资助金额:
    $ 0.1万
  • 项目类别:
Sidekick-1 Upregulation in Podocytes Induces FSGS by Disrupting MAGI-1 Function
足细胞中 Sidekick-1 上调通过破坏 MAGI-1 功能诱导 FSGS
  • 批准号:
    7695232
  • 财政年份:
    2009
  • 资助金额:
    $ 0.1万
  • 项目类别:
Sidekick-1 Upregulation in Podocytes Induces FSGS by Disrupting MAGI-1 Function
足细胞中 Sidekick-1 上调通过破坏 MAGI-1 功能诱导 FSGS
  • 批准号:
    8308636
  • 财政年份:
    2009
  • 资助金额:
    $ 0.1万
  • 项目类别:
Sidekick-1 Upregulation in Podocytes Induces FSGS by Disrupting MAGI-1 Function
足细胞中 Sidekick-1 上调通过破坏 MAGI-1 功能诱导 FSGS
  • 批准号:
    7912960
  • 财政年份:
    2009
  • 资助金额:
    $ 0.1万
  • 项目类别:
Sidekick-1 Upregulation in Podocytes Induces FSGS by Disrupting MAGI-1 Function
足细胞中 Sidekick-1 上调通过破坏 MAGI-1 功能诱导 FSGS
  • 批准号:
    8115089
  • 财政年份:
    2009
  • 资助金额:
    $ 0.1万
  • 项目类别:
Sidekick proteins in HIV-associated nephropathy
HIV 相关肾病中的 Sidekick 蛋白
  • 批准号:
    7039229
  • 财政年份:
    2005
  • 资助金额:
    $ 0.1万
  • 项目类别:

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