Identification and characterisation of novel copper homeostasis genes and proteins

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Copper is an essential nutrient that is also toxic when in excess. Specific mechanisms exist to regulate copper levels and these are conserved across many species. Disrupted copper regulation contributes to many diseases including: cardiovascular disease, osteoporosis and Alzheimer’s. I aim to identify and characterise novel copper regulatory proteins using the model organism Drosophila (vinegar fly) together with human cultured cells as a foundation for work to prevent or treat these diseases.