Stress, Blood Pressure and Ethnicity

压力、血压和种族

基本信息

批准号：
7679707
负责人：
JOEL E DIMSDALE
金额：
$ 67.09万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-06-16 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7679707
关键词：
Address Adrenergic Agents Adrenergic Receptor Affect African American Age Agonist Ambulatory Blood Pressure Monitoring American Anger Antihypertensive Agents Anxiety Arousal Autonomic nervous system Baroreflex Behavioral Biochemical Blood Pressure Blood Pressure Monitors Boston Breathing C-reactive protein Cardiovascular Diseases Cardiovascular system Catecholamines Clinical Research Complex Coping Behavior Data Analyses Disadvantaged Discrimination Disease Distress Doctor of Medicine Economics Enrollment Epidemiology Equipment and supply inventories Ethnic Origin Event Exposure to Family Fatigue Frequencies Functional disorder Genetic Goals Grant Heart Rate Hemostatic function Home environment Hour Hypertension Impedance Cardiography Individual Inflammation Inflammatory Response Infusion procedures Interleukin-6 Internet Investigation Isoproterenol Lead Life Stress Literature Lymphocyte Measures Mediating Modeling Monitor Moods Morbidity - disease rate Neighborhoods Nervous System Physiology Occupations Outpatients Parasympathetic Nervous System Patient Self-Report Patients Physiological Physiology Play Polysomnography Population Positioning Attribute Pressoreceptors Principal Investigator Procedures Pulse Pressure Questionnaires Race Regulation Research Research Personnel Rest Risk Role Running Sampling Sampling Studies Self Perception Severities Sleep Slow-Wave Sleep Stress Stress Tests Sympathetic Nervous System Testing Time Ultrasonography Unemployment Vascular Endothelium Vasoconstrictor Agents Vasodilation Work adrenergic blood pressure regulation brachial artery cardiovascular disorder risk cardiovascular risk factor depression depressive symptoms deprivation design ethnic difference experience healthy volunteer heart rate variability hemodynamics indexing inflammatory marker interest man mortality nutrition programs psychologic psychological stressor psychosocial respiratory response sleep onset social stressor tool

项目摘要

Psychosocial adversity and African-American ethnicity are both associated with increased risks for cardiovascular disease. This study examines possible underlying mechanisms of such increased risk and also examines how ethnicity and adversity interact in determining such risks. Specifically, this application proposes to scrutinize how ethnicity and adversity are related to blood pressure regulation, sleep, inflammatory markers, and the autonomic nervous system. One hundred African-American and 100 Euro-American subjects will be enrolled. Subjects will be either healthy volunteers or hypertensives not receiving anti-hypertensive therapy. Subjects will be admitted to the General Clinical Research Center for a 2-night stay during which they will complete overnight polysomnography, reactivity testing, and endothelial function testing. Vasoactive agonists will be infused and/or inhaled to assess baroreflex functioning, beta-adrenergic sensitivity, and vasodilatory response. Biochemical determinations will be made of their sympathetic nervous system functioning, as well as inflammatory response at rest and after exposure to short-term stressors. Subjects will complete questionnaires characterizing their exposure to stressors and their psychosocial functioning. They will also complete outpatient ambulatory blood pressure monitoring. This research will study mechanisms by which adversity increases cardiovascular risk. The study scrutinizes sleep, inflammation, vasodilation, autonomic functioning, and baroreflex regulation. We hypothesize that adversity has a stronger impact on cardiovascular pathophysiology than does ethnicity.

社会心理逆境和非裔美国人种族都与心血管疾病的风险增加有关。这项研究研究了这种增加的风险的潜在机制，还研究了种族和逆境在确定这种风险时如何相互作用。具体而言，该应用建议仔细检查种族和逆境如何与血压调节，睡眠，炎症标记和自主神经系统有关。将招募一百名非裔美国人和100名欧美人。受试者将是健康的志愿者或高血压，未接受抗高血压疗法。受试者将被送入一般临床研究中心，以进行2晚的住宿，在此期间，他们将完成隔夜多摄影术，反应性测试和内皮功能测试。血管活性激动剂将被注入和/或吸入以评估压力反射功能，β-肾上腺素能敏感性和血管舒张反应。生化测定将是对它们的交感神经系统功能的，以及在静止和暴露于短期应激源后的炎症反应。受试者将完成表征其压力源和社会心理功能的问卷调查。他们还将完成门诊门诊监测。这项研究将研究逆境增加心血管风险的机制。该研究仔细检查了睡眠，炎症，血管舒张，自主功能和压力反射调节。我们假设逆境对心血管病理生理学具有比种族更强大的影响。