REGARDS - MI Study

背景至于脑卒中，CHD死亡率的地理和种族差异得到了承认，但很少 明白NIH（NINDS）资助了中风的地理和种族差异的原因 （REGARDS）研究，随访30，000名个体（年龄>44岁; 1/2非洲裔美国人，1/2欧洲裔美国人; 1/2女性; 1/2来自卒中带/带扣区域）的卒中发病率和死亡率。 具体目标。REGARDS-MI辅助研究的总体目标是利用狭窄的 通过量化地理和种族差异来利用REGARD基础设施的机会窗口 在CHD死亡率，发病率（新发和复发性住院急性CHD和院前CHD死亡， 人群）和病死率（在急性CHD事件中，28天内死亡）。我们的具体 目的是（1）估计美国地理和种族特异性CHD死亡率、发病率和病例 死亡率;（2）研究美国地理和种族特异性攻击率与 冠心病危险因素的患病率;（3）研究美国地理和人种特异性 冠心病病死率与社会经济因素、医疗保健与冠心病危险因素有关。 方法.我们将检索所有心脏相关住院治疗的医疗记录（约6000）， 关注参与者并收集所有死亡数据（约500）。我们将裁定住院和死亡我们将裁定住院和死亡 对于冠心病，收集心脏手术和药物，并将其与已经在 收集的问候。使用多变量多水平分析，我们将测试10个特定的假设。 含义。这将是第一个将冠心病发病率和病死率联系起来的全国性研究， 院前死亡率与CHD死亡率的地理和种族差异有关。关注提供了一个独特的 有机会实现我们的具体目标，而不需要大量的参与者招募和后续费用， 否则就有必要了。REGARDS和REGARDS-MI之间没有预算重叠， REGARDS仅关注潜在的中风。我们的研究结果将大大有助于知识基础 这对于实现2010年健康人减少健康差距的目标至关重要。

BACKGROUND. As for stroke, geographic and ethnic variations in CHD mortality are recognized but poorly understood. NIH (NINDS) funded the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study to follow 30,000 individuals(age >44; 1/2 African American, 1/2 European American; 1/2 female; 1/2 from the stroke belt/ buckle areas) over 3.5 years for stroke incidence and mortality. SPECIFIC AIMS. The overall goal of the REGARDS-MI Ancillary Study is to capitalize on a narrow window of opportunity to leverage REGARD'S infrastructure by quantifying geographic and ethnic variations in CHD mortality, attack rates (new and recurrent hospitalized acute CHD and pre-hospital CHD death in the population) and case fatality (among those with an acute CHD event, death within 28 days). Our Specific Aims are to (1) estimate US geographic- and ethnic-specificrates of CHD mortality, attack rates, and case fatality; (2) study the relationshipbetween US geographic- and ethnic-specific attack rates and variation in the prevalence of CHD risk factors; and (3) study the relationship between US geographic- andethnic-specific CHD case fatality and socioeconomic factors, medical care and CHD risk factors. METHODS. We will retrieve medical records for all heart-related hospitalizations(-6000) among REGARDS participants and collect data on all deaths (-500). We will adjudicatehospitalizations and deaths for CHD, collect cardiac procedures and medications, and merge this with extensive data already being collected by REGARDS. Using multivariable multi-levelanalyses, we will test 10 specific hypotheses. IMPLICATIONS. This will be the first nationwidestudy to relate CHD attack rate and case fatality, including pre-hospital deaths, to geographic and ethnic variations in CHD mortality. REGARDS offers aunique opportunity to attain our specific aims without the massive participant recruitment and follow-up costs that otherwise would be necessary. There is no budgetary overlap between REGARDS and REGARDS-MI as REGARDS focuses only on potential strokes. Our results will contribute significantlyto the knowledge base essential for attaining the Healthy People 2010 goal of reducing health disparities.