REGARDS - MI Study

背景资料。至于中风，冠心病死亡率的地理和种族差异是公认的，但很少。 明白了。美国国立卫生研究院(NINDS)资助了中风的地理和种族差异的原因 (关于)跟踪研究30,000人(44岁；1/2非裔美国人，1/2欧洲裔美国人； 1/2女性；1/2来自卒中腰带/扣区)超过3.5年的中风发病率和死亡率。 明确的目标。CORETS-MI辅助研究的总体目标是利用狭义的 通过量化地理和种族差异来利用REAT基础设施的机会之窗 在冠心病死亡率、发病率(首次和复发住院的急性冠心病和院前冠心病死亡)中 病死率(在有急性冠心病事件的人中，在28天内死亡)。我们的特定 目的是(1)估计美国特定地域和种族的冠心病死亡率、发病率和病例 致死率；(2)研究美国特定地理和种族的发病率之间的关系以及 冠心病危险因素的患病率；以及(3)研究美国地理和特定技术之间的关系 冠心病病死率与社会经济因素、医疗保健与冠心病危险因素。 方法：研究方法。我们将检索所有与心脏相关的住院(-6000)的医疗记录 关于参与者并收集所有死亡人数的数据(-500)。我们将裁决住院和死亡 对于CHD，收集心脏手术和药物，并将其与已经存在的大量数据合并 由问候收集。使用多变量多水平分析，我们将检验10个具体的假设。 这意味着什么。这将是第一个全国性的关于冠心病发病率和病死率之间关系的研究，包括 院前死亡与冠心病死亡率的地理和种族差异有关。将优惠视为独一无二 无需大规模招募参与者和后续成本即可实现特定目标的机会 否则将是必要的。视和视-MI AS之间没有预算重叠 仅关注潜在的笔划。我们的结果将对知识库做出重大贡献 这对于实现2010年健康人减少健康差距的目标至关重要。

BACKGROUND. As for stroke, geographic and ethnic variations in CHD mortality are recognized but poorly understood. NIH (NINDS) funded the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study to follow 30,000 individuals(age >44; 1/2 African American, 1/2 European American; 1/2 female; 1/2 from the stroke belt/ buckle areas) over 3.5 years for stroke incidence and mortality. SPECIFIC AIMS. The overall goal of the REGARDS-MI Ancillary Study is to capitalize on a narrow window of opportunity to leverage REGARD'S infrastructure by quantifying geographic and ethnic variations in CHD mortality, attack rates (new and recurrent hospitalized acute CHD and pre-hospital CHD death in the population) and case fatality (among those with an acute CHD event, death within 28 days). Our Specific Aims are to (1) estimate US geographic- and ethnic-specificrates of CHD mortality, attack rates, and case fatality; (2) study the relationshipbetween US geographic- and ethnic-specific attack rates and variation in the prevalence of CHD risk factors; and (3) study the relationship between US geographic- andethnic-specific CHD case fatality and socioeconomic factors, medical care and CHD risk factors. METHODS. We will retrieve medical records for all heart-related hospitalizations(-6000) among REGARDS participants and collect data on all deaths (-500). We will adjudicatehospitalizations and deaths for CHD, collect cardiac procedures and medications, and merge this with extensive data already being collected by REGARDS. Using multivariable multi-levelanalyses, we will test 10 specific hypotheses. IMPLICATIONS. This will be the first nationwidestudy to relate CHD attack rate and case fatality, including pre-hospital deaths, to geographic and ethnic variations in CHD mortality. REGARDS offers aunique opportunity to attain our specific aims without the massive participant recruitment and follow-up costs that otherwise would be necessary. There is no budgetary overlap between REGARDS and REGARDS-MI as REGARDS focuses only on potential strokes. Our results will contribute significantlyto the knowledge base essential for attaining the Healthy People 2010 goal of reducing health disparities.